{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(11)"],"submitter":["Nakamura K"],"funding":["Meiji Co., Ltd."],"pubmed_abstract":["Cancer chemotherapy is frequently accompanied by adverse effects, such as diarrhoea and leukopenia, which lead to malnutrition and a decrease in the patients' quality of life. We previously demonstrated that an immune-modulating formula (IMF)-an enteral formula enriched with immunonutrients, whey-hydrolysed peptides, and fermented milk-had anti-inflammatory effects and protective effects on intestinal disorders in some experimental models. Here, we investigated whether nutritional treatment with the IMF could prevent 5-fluorouracil (5-FU)-induced adverse effects in rats. Rats were randomised into CTR and IMF groups, which received a control formula or the IMD supplemented formula ad libitum. Two weeks after starting the formula, rats were intraperitoneally injected with 5-FU (300 mg/kg) on"],"journal":["PloS one"],"pagination":["e0225389"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6879153"],"repository":["biostudies-literature"],"pubmed_title":["Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats."],"pmcid":["PMC6879153"],"pubmed_authors":["Yamaji T","Nakamura K","Tonouchi H","Sasayama A","Ashida K"],"additional_accession":[]},"is_claimable":false,"name":"Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats.","description":"Cancer chemotherapy is frequently accompanied by adverse effects, such as diarrhoea and leukopenia, which lead to malnutrition and a decrease in the patients' quality of life. We previously demonstrated that an immune-modulating formula (IMF)-an enteral formula enriched with immunonutrients, whey-hydrolysed peptides, and fermented milk-had anti-inflammatory effects and protective effects on intestinal disorders in some experimental models. Here, we investigated whether nutritional treatment with the IMF could prevent 5-fluorouracil (5-FU)-induced adverse effects in rats. Rats were randomised into CTR and IMF groups, which received a control formula or the IMD supplemented formula ad libitum. Two weeks after starting the formula, rats were intraperitoneally injected with 5-FU (300 mg/kg) on","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-18T15:33:22.007Z","creation":"2020-05-21T21:19:07Z"},"accession":"S-EPMC6879153","cross_references":{"pubmed":["31770400"],"doi":["10.1371/journal.pone.0225389"]}}