biostudies-literatureUnknown14(11)Nakamura KMeiji Co., Ltd.Cancer chemotherapy is frequently accompanied by adverse effects, such as diarrhoea and leukopenia, which lead to malnutrition and a decrease in the patients' quality of life. We previously demonstrated that an immune-modulating formula (IMF)-an enteral formula enriched with immunonutrients, whey-hydrolysed peptides, and fermented milk-had anti-inflammatory effects and protective effects on intestinal disorders in some experimental models. Here, we investigated whether nutritional treatment with the IMF could prevent 5-fluorouracil (5-FU)-induced adverse effects in rats. Rats were randomised into CTR and IMF groups, which received a control formula or the IMD supplemented formula ad libitum. Two weeks after starting the formula, rats were intraperitoneally injected with 5-FU (300 mg/kg) onPloS onee0225389https://www.ebi.ac.uk/biostudies/studies/S-EPMC6879153biostudies-literatureNutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats.PMC6879153Yamaji TNakamura KTonouchi HSasayama AAshida KfalseNutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats.Cancer chemotherapy is frequently accompanied by adverse effects, such as diarrhoea and leukopenia, which lead to malnutrition and a decrease in the patients' quality of life. We previously demonstrated that an immune-modulating formula (IMF)-an enteral formula enriched with immunonutrients, whey-hydrolysed peptides, and fermented milk-had anti-inflammatory effects and protective effects on intestinal disorders in some experimental models. Here, we investigated whether nutritional treatment with the IMF could prevent 5-fluorouracil (5-FU)-induced adverse effects in rats. Rats were randomised into CTR and IMF groups, which received a control formula or the IMD supplemented formula ad libitum. Two weeks after starting the formula, rats were intraperitoneally injected with 5-FU (300 mg/kg) on2019-01-01T00:00:00Z20192025-04-18T15:33:22.007Z2020-05-21T21:19:07ZS-EPMC68791533177040010.1371/journal.pone.0225389