biostudies-literatureLai BNIDDK NIH HHSNHLBI NIH HHSNIH HHS2612https://www.ebi.ac.uk/biostudies/studies/S-EPMC6880770biostudies-literatureUnknown10The mechanisms underlying pathophysiological regulation of tissue macrophage (Mφ) subsets remain poorly understood. From the expression of 207 Mφ genes comprising 31 markers for 10 subsets, 45 transcription factors (TFs), 56 immunometabolism enzymes, 23 trained immunity (innate immune memory) enzymes, and 52 other genes in microarray data, we made the following findings. (1) When 34 inflammation diseases and tumor types were grouped into eight categories, there was differential expression of the 31 Mφ markers and 45 Mφ TFs, highlighted by 12 shared and 20 group-specific disease pathways. (2) Mφ in lung, liver, spleen, and intestine (LLSI-Mφ) express higher M1 Mφ markers than lean adipose tissue Mφ (ATMφ) physiologically. (3) Pro-adipogenic TFs C/EBPα and PPARγ and proinflammatory adipokineFrontiers in immunologyTwenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors.PMC6880770R01 HL130233P51 OD011104R01 HL117654R01 HL132399R01 HL131460R01 HL147565R01 DK113775R01 DK104116R01 HL138749Lu YSaaoud FQin XLai BYu DWang HYu JRogers TWang JZhang RShen YHYang WYSun LFagenson ANanayakkara GShao YChoi ETWu SMastascusa KJohnson CSun JFan DXu KSaredy JDrummer CSun YCueto RYang XZhu PFu HYang QfalseTwenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors.The mechanisms underlying pathophysiological regulation of tissue macrophage (Mφ) subsets remain poorly understood. From the expression of 207 Mφ genes comprising 31 markers for 10 subsets, 45 transcription factors (TFs), 56 immunometabolism enzymes, 23 trained immunity (innate immune memory) enzymes, and 52 other genes in microarray data, we made the following findings. (1) When 34 inflammation diseases and tumor types were grouped into eight categories, there was differential expression of the 31 Mφ markers and 45 Mφ TFs, highlighted by 12 shared and 20 group-specific disease pathways. (2) Mφ in lung, liver, spleen, and intestine (LLSI-Mφ) express higher M1 Mφ markers than lean adipose tissue Mφ (ATMφ) physiologically. (3) Pro-adipogenic TFs C/EBPα and PPARγ and proinflammatory adipokine2019-01-01T00:00:00Z20192026-04-08T13:45:19.921Z2020-05-21T22:06:46ZS-EPMC68807703182448010.3389/fimmu.2019.02612