{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lorenz DR"],"funding":["NCATS NIH HHS","NIDA NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NIMH NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["59"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6883692"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["<h4>Background</h4>Tobacco smoking induces immunomodulatory and pro-inflammatory effects associated with transcriptome changes in monocytes and other immune cell types. While smoking is prevalent in HIV-infected (HIV+) individuals, few studies have investigated its effects on gene expression in this population. Here, we report whole-transcriptome analyses of 125 peripheral blood monocyte samples from ART-treated HIV+ and uninfected (HIV-) men enrolled in the Multicenter AIDS Cohort Study (MACS) (n = 25 HIV+ smokers, n = 60 HIV+ non-smokers, n = 40 HIV- non-smoking controls). Gene expression profiling was performed using Illumina HumanHT-12 Expression BeadChip microarrays. Differential expression analysis was performed with weighted linear regression models using the R limma package, follow"],"journal":["Human genomics"],"pubmed_title":["Transcriptomic analysis of monocytes from HIV-positive men on antiretroviral therapy reveals effects of tobacco smoking on interferon and stress response systems associated with depressive symptoms."],"pmcid":["PMC6883692"],"funding_grant_id":["U01 AI035041","MH110259","U01 AI035043","DA046203","U01 AI035042","DA40391","R01 DA046203","U01 HL146201","UL1 TR000424","R01 MH110259","U01 AI035039","R01 DA040391"],"pubmed_authors":["Gabuzda D","Lorenz DR","Misra V"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic analysis of monocytes from HIV-positive men on antiretroviral therapy reveals effects of tobacco smoking on interferon and stress response systems associated with depressive symptoms.","description":"<h4>Background</h4>Tobacco smoking induces immunomodulatory and pro-inflammatory effects associated with transcriptome changes in monocytes and other immune cell types. While smoking is prevalent in HIV-infected (HIV+) individuals, few studies have investigated its effects on gene expression in this population. Here, we report whole-transcriptome analyses of 125 peripheral blood monocyte samples from ART-treated HIV+ and uninfected (HIV-) men enrolled in the Multicenter AIDS Cohort Study (MACS) (n = 25 HIV+ smokers, n = 60 HIV+ non-smokers, n = 40 HIV- non-smoking controls). Gene expression profiling was performed using Illumina HumanHT-12 Expression BeadChip microarrays. Differential expression analysis was performed with weighted linear regression models using the R limma package, follow","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2026-05-04T11:34:02.47Z","creation":"2020-05-21T21:04:15Z"},"accession":"S-EPMC6883692","cross_references":{"pubmed":["31779701"],"doi":["10.1186/s40246-019-0247-x"]}}