biostudies-literatureUnknown9(1)Li JCSNK2B, which encodes the beta subunit of casein kinase II (CK2), plays an important role in neuron morphology and synaptic transmission. Variants in CSNK2B associated with epilepsy and/or intellectual disability (ID)/developmental delay (DD) have been reported in five cases only. Among the 816 probands suspected hereditary epilepsy whose initial report of trio-based whole exome sequencing (WES) were negative, 10 de novo pathogenic or likely pathogenic variants of CSNK2B in nine probands were identified after reanalysis of their raw Trio-WES data. Six of the nine epileptic patients had ID/DD. The age of seizure onset of these nine patients with CSNK2B variants ranged from 2-12 months. Eight patients had age of seizure onset of less than 6 months. The epilepsy of most probands (8/9) was genScientific reports17909https://www.ebi.ac.uk/biostudies/studies/S-EPMC6884442biostudies-literatureGermline de novo variants in CSNK2B in Chinese patients with epilepsy.PMC6884442Li JCai SYu SHu WWang JJiang YLiu YHuang SYang ZXie HGao KZha JWang YYan HWu YfalseGermline de novo variants in CSNK2B in Chinese patients with epilepsy.CSNK2B, which encodes the beta subunit of casein kinase II (CK2), plays an important role in neuron morphology and synaptic transmission. Variants in CSNK2B associated with epilepsy and/or intellectual disability (ID)/developmental delay (DD) have been reported in five cases only. Among the 816 probands suspected hereditary epilepsy whose initial report of trio-based whole exome sequencing (WES) were negative, 10 de novo pathogenic or likely pathogenic variants of CSNK2B in nine probands were identified after reanalysis of their raw Trio-WES data. Six of the nine epileptic patients had ID/DD. The age of seizure onset of these nine patients with CSNK2B variants ranged from 2-12 months. Eight patients had age of seizure onset of less than 6 months. The epilepsy of most probands (8/9) was gen2019-01-01T00:00:00Z2019 Nov2026-06-12T05:32:57.373Z2025-05-29T21:37:25.755ZS-EPMC68844423178456010.1038/s41598-019-53484-9