{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kiss T"],"funding":["NIA NIH HHS","NINDS NIH HHS","NIGMS NIH HHS","National Institute on Aging"],"pagination":["619-630"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6885080"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(5)"],"pubmed_abstract":["Age-related impairment of angiogenesis likely has a critical role in cerebromicrovascular rarefaction and development of vascular cognitive impairment and dementia (VCID) in the elderly. Recently, we demonstrated that aging is associated with NAD<sup>+</sup> depletion in the vasculature and that administration of NAD<sup>+</sup> precursors exerts potent anti-aging vascular effects, rescuing endothelium-mediated vasodilation in the cerebral circulation and improving cerebral blood supply. The present study was designed to elucidate how treatment with nicotinamide mononucleotide (NMN), a key NAD<sup>+</sup> intermediate, impacts age-related impairment of endothelial angiogenic processes. Using cerebromicrovascular endothelial cells (CMVECs) isolated from young and aged F344xBN rats, we demon"],"journal":["GeroScience"],"pubmed_title":["Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment."],"pmcid":["PMC6885080"],"funding_grant_id":["U54 GM104938","R01 AG047879","R01-AG038747","R01-AG047879","P20 GM125528","P20 GM103447","R01 NS056218","R01 AG055395","R01 NS100782","R01-AG055395"],"pubmed_authors":["Valcarcel-Ares MN","Farkas E","Zhang XA","Yabluchanskiy A","Kiss T","Balasubramanian P","Lipecz A","Ungvari Z","Bari F","Tarantini S","Csiszar A","Csipo T","Reglodi D"],"additional_accession":[]},"is_claimable":false,"name":"Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.","description":"Age-related impairment of angiogenesis likely has a critical role in cerebromicrovascular rarefaction and development of vascular cognitive impairment and dementia (VCID) in the elderly. Recently, we demonstrated that aging is associated with NAD<sup>+</sup> depletion in the vasculature and that administration of NAD<sup>+</sup> precursors exerts potent anti-aging vascular effects, rescuing endothelium-mediated vasodilation in the cerebral circulation and improving cerebral blood supply. The present study was designed to elucidate how treatment with nicotinamide mononucleotide (NMN), a key NAD<sup>+</sup> intermediate, impacts age-related impairment of endothelial angiogenic processes. Using cerebromicrovascular endothelial cells (CMVECs) isolated from young and aged F344xBN rats, we demon","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2025-04-26T10:11:02.382Z","creation":"2020-05-21T23:25:48Z"},"accession":"S-EPMC6885080","cross_references":{"pubmed":["31144244"],"doi":["10.1007/s11357-019-00074-2"]}}