biostudies-literatureKiss TNIA NIH HHSNINDS NIH HHSNIGMS NIH HHSNational Institute on Aging619-630https://www.ebi.ac.uk/biostudies/studies/S-EPMC6885080biostudies-literatureUnknown41(5)Age-related impairment of angiogenesis likely has a critical role in cerebromicrovascular rarefaction and development of vascular cognitive impairment and dementia (VCID) in the elderly. Recently, we demonstrated that aging is associated with NAD⁺ depletion in the vasculature and that administration of NAD⁺ precursors exerts potent anti-aging vascular effects, rescuing endothelium-mediated vasodilation in the cerebral circulation and improving cerebral blood supply. The present study was designed to elucidate how treatment with nicotinamide mononucleotide (NMN), a key NAD⁺ intermediate, impacts age-related impairment of endothelial angiogenic processes. Using cerebromicrovascular endothelial cells (CMVECs) isolated from young and aged F344xBN rats, we demonGeroScienceNicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.PMC6885080U54 GM104938R01 AG047879R01-AG038747R01-AG047879P20 GM125528P20 GM103447R01 NS056218R01 AG055395R01 NS100782R01-AG055395Valcarcel-Ares MNFarkas EZhang XAYabluchanskiy AKiss TBalasubramanian PLipecz AUngvari ZBari FTarantini SCsiszar ACsipo TReglodi DfalseNicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.Age-related impairment of angiogenesis likely has a critical role in cerebromicrovascular rarefaction and development of vascular cognitive impairment and dementia (VCID) in the elderly. Recently, we demonstrated that aging is associated with NAD⁺ depletion in the vasculature and that administration of NAD⁺ precursors exerts potent anti-aging vascular effects, rescuing endothelium-mediated vasodilation in the cerebral circulation and improving cerebral blood supply. The present study was designed to elucidate how treatment with nicotinamide mononucleotide (NMN), a key NAD⁺ intermediate, impacts age-related impairment of endothelial angiogenic processes. Using cerebromicrovascular endothelial cells (CMVECs) isolated from young and aged F344xBN rats, we demon2019-01-01T00:00:00Z2019 Oct2025-04-26T10:11:02.382Z2020-05-21T23:25:48ZS-EPMC68850803114424410.1007/s11357-019-00074-2