{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Williams AM"],"funding":["Division of Nutrition, Physical Activity, and Obesity","Robert W Woodruff Health Sciences Center Fund, Inc.","Agriculture and Food Research Initiative Competitive","USDA","National Institute of Food and Agriculture","NIGMS NIH HHS","Intramural CDC HHS"],"pagination":["1456-1464"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6885472"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["110(6)"],"pubmed_abstract":["<h4>Background</h4>To accurately assess micronutrient status, it is necessary to characterize the effects of inflammation and the acute-phase response on nutrient biomarkers.<h4>Objective</h4>Within a norovirus human challenge study, we aimed to model the inflammatory response of C-reactive protein (CRP) and α-1-acid glycoprotein (AGP) by infection status, model kinetics of micronutrient biomarkers by inflammation status, and evaluate associations between inflammation and micronutrient biomarkers from 0 to 35 d post-norovirus exposure.<h4>Methods</h4>Fifty-two healthy adults were enrolled into challenge studies in a hospital setting and followed longitudinally; all were exposed to norovirus, half were infected. Post hoc analysis of inflammatory and nutritional biomarkers was performed. Sub"],"journal":["The American journal of clinical nutrition"],"pubmed_title":["Changes in micronutrient and inflammation serum biomarker concentrations after a norovirus human challenge."],"pmcid":["PMC6885472"],"funding_grant_id":["CC999999","R01 GM124280","2011-68003-30395","2015-67017-23080"],"pubmed_authors":["Williams AM","Lopman BA","Thurnham D","Suchdev PS","Whitehead RD","Pasricha SR","Leon JS","Tangpricha V","Ladva CN","Wray K","Allen L","Flores-Ayala RC","Tanumihardjo SA","Armitage AE","Shahab-Ferdows S","Morovat A"],"additional_accession":[]},"is_claimable":false,"name":"Changes in micronutrient and inflammation serum biomarker concentrations after a norovirus human challenge.","description":"<h4>Background</h4>To accurately assess micronutrient status, it is necessary to characterize the effects of inflammation and the acute-phase response on nutrient biomarkers.<h4>Objective</h4>Within a norovirus human challenge study, we aimed to model the inflammatory response of C-reactive protein (CRP) and α-1-acid glycoprotein (AGP) by infection status, model kinetics of micronutrient biomarkers by inflammation status, and evaluate associations between inflammation and micronutrient biomarkers from 0 to 35 d post-norovirus exposure.<h4>Methods</h4>Fifty-two healthy adults were enrolled into challenge studies in a hospital setting and followed longitudinally; all were exposed to norovirus, half were infected. Post hoc analysis of inflammatory and nutritional biomarkers was performed. Sub","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2026-04-07T20:37:39.375Z","creation":"2020-05-21T21:01:32Z"},"accession":"S-EPMC6885472","cross_references":{"pubmed":["31504095"],"doi":["10.1093/ajcn/nqz201"]}}