biostudies-literatureWilliams AMDivision of Nutrition, Physical Activity, and ObesityRobert W Woodruff Health Sciences Center Fund, Inc.Agriculture and Food Research Initiative CompetitiveUSDANational Institute of Food and AgricultureNIGMS NIH HHSIntramural CDC HHS1456-1464https://www.ebi.ac.uk/biostudies/studies/S-EPMC6885472biostudies-literatureUnknown110(6)<h4>Background</h4>To accurately assess micronutrient status, it is necessary to characterize the effects of inflammation and the acute-phase response on nutrient biomarkers.<h4>Objective</h4>Within a norovirus human challenge study, we aimed to model the inflammatory response of C-reactive protein (CRP) and α-1-acid glycoprotein (AGP) by infection status, model kinetics of micronutrient biomarkers by inflammation status, and evaluate associations between inflammation and micronutrient biomarkers from 0 to 35 d post-norovirus exposure.<h4>Methods</h4>Fifty-two healthy adults were enrolled into challenge studies in a hospital setting and followed longitudinally; all were exposed to norovirus, half were infected. Post hoc analysis of inflammatory and nutritional biomarkers was performed. SubThe American journal of clinical nutritionChanges in micronutrient and inflammation serum biomarker concentrations after a norovirus human challenge.PMC6885472CC999999R01 GM1242802011-68003-303952015-67017-23080Williams AMLopman BAThurnham DSuchdev PSWhitehead RDPasricha SRLeon JSTangpricha VLadva CNWray KAllen LFlores-Ayala RCTanumihardjo SAArmitage AEShahab-Ferdows SMorovat AfalseChanges in micronutrient and inflammation serum biomarker concentrations after a norovirus human challenge.<h4>Background</h4>To accurately assess micronutrient status, it is necessary to characterize the effects of inflammation and the acute-phase response on nutrient biomarkers.<h4>Objective</h4>Within a norovirus human challenge study, we aimed to model the inflammatory response of C-reactive protein (CRP) and α-1-acid glycoprotein (AGP) by infection status, model kinetics of micronutrient biomarkers by inflammation status, and evaluate associations between inflammation and micronutrient biomarkers from 0 to 35 d post-norovirus exposure.<h4>Methods</h4>Fifty-two healthy adults were enrolled into challenge studies in a hospital setting and followed longitudinally; all were exposed to norovirus, half were infected. Post hoc analysis of inflammatory and nutritional biomarkers was performed. Sub2019-01-01T00:00:00Z2019 Dec2026-04-07T20:37:39.375Z2020-05-21T21:01:32ZS-EPMC68854723150409510.1093/ajcn/nqz201