{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen Q"],"funding":["National Natural Science Foundation of China"],"pagination":["786-795"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6889176"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(9)"],"pubmed_abstract":["<h4>Background</h4>The progression and metastasis of pancreatic ductal adenocarcinoma (PDAC) is highly dependent on the tumour microenvironment. Most tumour-associated macrophages (TAMs) are M2 phenotype macrophages, which normally show anti-inflammatory functions in numerous disorders. Previously, we found that alternatively activated macrophages showed pro-inflammatory characteristics upon stimulation with hepatoma cell-derived debris; however, the molecular mechanism was unclear.<h4>Methods</h4>In vitro and in vivo experiments were employed to investigate the molecular mechanism. Using pancreatic cancer cell lines, mouse models and human tissues, we obtained a general picture of tumour cell-derived debris promoting metastasis of pancreatic cancer by inducing inflammation via TAMs.<h4>Re"],"journal":["British journal of cancer"],"pubmed_title":["Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages."],"pmcid":["PMC6889176"],"funding_grant_id":["81530079","2015AA020405"],"pubmed_authors":["Fu Q","Liang T","Chen Q","Yang J","Zhang J","Lou Y","Wang J","Bai X","Zhang Q","Ye M","Wei T","Zhang X","Chen Y","Dang X"],"additional_accession":[]},"is_claimable":false,"name":"Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages.","description":"<h4>Background</h4>The progression and metastasis of pancreatic ductal adenocarcinoma (PDAC) is highly dependent on the tumour microenvironment. Most tumour-associated macrophages (TAMs) are M2 phenotype macrophages, which normally show anti-inflammatory functions in numerous disorders. Previously, we found that alternatively activated macrophages showed pro-inflammatory characteristics upon stimulation with hepatoma cell-derived debris; however, the molecular mechanism was unclear.<h4>Methods</h4>In vitro and in vivo experiments were employed to investigate the molecular mechanism. Using pancreatic cancer cell lines, mouse models and human tissues, we obtained a general picture of tumour cell-derived debris promoting metastasis of pancreatic cancer by inducing inflammation via TAMs.<h4>Re","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2025-04-18T23:42:40.904Z","creation":"2020-05-21T20:33:03Z"},"accession":"S-EPMC6889176","cross_references":{"pubmed":["31588122"],"doi":["10.1038/s41416-019-0595-2"]}}