{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li J"],"funding":["National Basic Research Program of China","National Natural Science Foundation of China"],"pagination":["9099-9103"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6889834"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(39)"],"pubmed_abstract":["The transformations of unactivated alkenes through C[double bond, length as m-dash]C bond double cleavage are always attractive but very challenging. We report herein a chemoselective approach to valuable cyclic imides by a novel Cu-catalyzed geminal amino-oxygenation of unactivated C[double bond, length as m-dash]C bonds. O<sub>2</sub> was successfully employed as the oxidant as well as the O-source and was incorporated into alkenyl amides <i>via</i> C[double bond, length as m-dash]C bond cleavage for the efficient preparation of succinimide or glutarimide derivatives. Moreover, the present strategy under simple conditions can be used in the late-stage modification of biologically active compounds and the synthesis of pharmaceuticals, which demonstrated the potential application."],"journal":["Chemical science"],"pubmed_title":["Cu-catalyzed oxygenation of alkene-tethered amides with O<sub>2</sub> <i>via</i> unactivated C[double bond, length as m-dash]C bond cleavage: a direct approach to cyclic imides."],"pmcid":["PMC6889834"],"funding_grant_id":["2015CB856600","21772002","21632001","81821004"],"pubmed_authors":["Jiao N","Li J","Wang T","Wei J","Zhu B"],"additional_accession":[]},"is_claimable":false,"name":"Cu-catalyzed oxygenation of alkene-tethered amides with O<sub>2</sub> <i>via</i> unactivated C[double bond, length as m-dash]C bond cleavage: a direct approach to cyclic imides.","description":"The transformations of unactivated alkenes through C[double bond, length as m-dash]C bond double cleavage are always attractive but very challenging. We report herein a chemoselective approach to valuable cyclic imides by a novel Cu-catalyzed geminal amino-oxygenation of unactivated C[double bond, length as m-dash]C bonds. O<sub>2</sub> was successfully employed as the oxidant as well as the O-source and was incorporated into alkenyl amides <i>via</i> C[double bond, length as m-dash]C bond cleavage for the efficient preparation of succinimide or glutarimide derivatives. Moreover, the present strategy under simple conditions can be used in the late-stage modification of biologically active compounds and the synthesis of pharmaceuticals, which demonstrated the potential application.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2025-04-04T20:45:22.775Z","creation":"2025-04-04T20:45:22.775Z"},"accession":"S-EPMC6889834","cross_references":{"pubmed":["31827752"],"doi":["10.1039/c9sc03175h"]}}