{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pan SP"],"funding":["Austrian Science Fund FWF"],"pagination":["1351"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6892967"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["In order to identify active constituents and to gain some information regarding their mode of action, extracts from leaves of <i>Epipremnum pinnatum</i> were tested for their ability to inhibit inflammatory gene expression in endothelial- and monocyte-like cells (HUVECtert and THP-1, respectively). Bioactivity-guided fractionation using expression of <i>PTGS2</i> (COX-2) mRNA as a readout resulted in the isolation of two C13 megastigmane glycosides, gusanlungionoside C (<b>1</b>) and citroside A (<b>3</b>), and the phenylalcohol glycoside phenylmethyl-2-<i>O</i>-(6-<i>O</i>-rhamnosyl)-ß-D-galactopyranoside (<b>2</b>). Further analysis identified six additional megastigmane glycosides and the aglycones β-damascenone (<b>10</b>), megastigmatrienone (<b>11</b>), 3-hydroxy-β-damascenone (<b>12"],"journal":["Frontiers in pharmacology"],"pubmed_title":["C13 Megastigmane Derivatives From <i>Epipremnum pinnatum:</i> β-Damascenone Inhibits the Expression of Pro-Inflammatory Cytokines and Leukocyte Adhesion Molecules as Well as NF-κB Signaling."],"pmcid":["PMC6892967"],"funding_grant_id":["P 27682","P 27682-B30"],"pubmed_authors":["Kretschmer N","Rappai J","Dirsch VM","Bauer R","Bochkov V","Kunert O","Pirker T","Hummelbrunner S","Pan SP","Latkolik SL"],"additional_accession":[]},"is_claimable":false,"name":"C13 Megastigmane Derivatives From <i>Epipremnum pinnatum:</i> β-Damascenone Inhibits the Expression of Pro-Inflammatory Cytokines and Leukocyte Adhesion Molecules as Well as NF-κB Signaling.","description":"In order to identify active constituents and to gain some information regarding their mode of action, extracts from leaves of <i>Epipremnum pinnatum</i> were tested for their ability to inhibit inflammatory gene expression in endothelial- and monocyte-like cells (HUVECtert and THP-1, respectively). Bioactivity-guided fractionation using expression of <i>PTGS2</i> (COX-2) mRNA as a readout resulted in the isolation of two C13 megastigmane glycosides, gusanlungionoside C (<b>1</b>) and citroside A (<b>3</b>), and the phenylalcohol glycoside phenylmethyl-2-<i>O</i>-(6-<i>O</i>-rhamnosyl)-ß-D-galactopyranoside (<b>2</b>). Further analysis identified six additional megastigmane glycosides and the aglycones β-damascenone (<b>10</b>), megastigmatrienone (<b>11</b>), 3-hydroxy-β-damascenone (<b>12","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-25T21:08:02.105Z","creation":"2020-05-22T00:01:40Z"},"accession":"S-EPMC6892967","cross_references":{"pubmed":["31849641"],"doi":["10.3389/fphar.2019.01351"]}}