{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Zhao S"],"funding":["Beijing Municipal Science and Technology Commission","National Natural Science Foundation of China"],"pubmed_abstract":["The 14-3-3 protein family has attracted much attention in research into the pathogenesis of human tumors because of its involvement in tumorigenesis. In previous studies, we found that 14-3-3η was highly expressed in pituitary oncocytoma. However, the mechanism by which 14-3-3η regulates tumorigenesis in pituitary oncocytoma is unclear. 14-3-3η-binding proteins were investigated in pituitary oncocytoma by immunoprecipitation and proteomic analysis. A total of 443 proteins were identified as 14-3-3η binding proteins. The interactions of 14-3-3η and its binding partners were identified by a network analysis using the STRING database. The network included 433 nodes and 564 edges. PRAS40 (AKT1S1) was a binding protein of 14-3-3η and showed experimental interactions with 14-3-3η in the STRING d"],"journal":["Frontiers in endocrinology"],"pagination":["797"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6893364"],"repository":["biostudies-literature"],"pubmed_title":["The Apoptosis Regulator 14-3-3η and Its Potential as a Therapeutic Target in Pituitary Oncocytoma."],"pmcid":["PMC6893364"],"pubmed_authors":["Zhao S","Li C","He Y","Feng J","Li D","Zhang Y","Miao Y","Gong L","Li B","Gao H","Wang H"],"additional_accession":[]},"is_claimable":false,"name":"The Apoptosis Regulator 14-3-3η and Its Potential as a Therapeutic Target in Pituitary Oncocytoma.","description":"The 14-3-3 protein family has attracted much attention in research into the pathogenesis of human tumors because of its involvement in tumorigenesis. In previous studies, we found that 14-3-3η was highly expressed in pituitary oncocytoma. However, the mechanism by which 14-3-3η regulates tumorigenesis in pituitary oncocytoma is unclear. 14-3-3η-binding proteins were investigated in pituitary oncocytoma by immunoprecipitation and proteomic analysis. A total of 443 proteins were identified as 14-3-3η binding proteins. The interactions of 14-3-3η and its binding partners were identified by a network analysis using the STRING database. The network included 433 nodes and 564 edges. PRAS40 (AKT1S1) was a binding protein of 14-3-3η and showed experimental interactions with 14-3-3η in the STRING d","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-05-04T01:04:03.516Z","creation":"2020-05-22T00:01:43Z"},"accession":"S-EPMC6893364","cross_references":{"pubmed":["31849836"],"doi":["10.3389/fendo.2019.00797"]}}