{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(11)"],"submitter":["Malik T"],"pubmed_abstract":["Mumps virus (MuV) is a neurotropic non-segmented, negative-stranded, enveloped RNA virus in the <i>Paramyxovirus</i> family. The 15.4 kb genome encodes seven genes, including the V/P, which encodes, among other proteins, the V protein. The MuV V protein has been shown to target the cellular signal transducer and activator of transcription proteins STAT1 and STAT3 for proteasome-mediated degradation. While MuV V protein targeting of STAT1 is generally accepted as a means of limiting innate antiviral responses, the consequence of V protein targeting of STAT3 is less clear. Further, since the MuV V protein targets both STAT1 and STAT3, specifically investigating viral antagonism of STAT3 targeting is challenging. However, a previous study reported that a single amino acid substitution in the "],"journal":["Viruses"],"pagination":["E1016"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6893744"],"repository":["biostudies-literature"],"pubmed_title":["A Single Point Mutation in the Mumps V Protein Alters Targeting of the Cellular STAT Pathways Resulting in Virus Attenuation."],"pmcid":["PMC6893744"],"pubmed_authors":["Bosma T","Malik T","Ngo L","Rubin S"],"additional_accession":[]},"is_claimable":false,"name":"A Single Point Mutation in the Mumps V Protein Alters Targeting of the Cellular STAT Pathways Resulting in Virus Attenuation.","description":"Mumps virus (MuV) is a neurotropic non-segmented, negative-stranded, enveloped RNA virus in the <i>Paramyxovirus</i> family. The 15.4 kb genome encodes seven genes, including the V/P, which encodes, among other proteins, the V protein. The MuV V protein has been shown to target the cellular signal transducer and activator of transcription proteins STAT1 and STAT3 for proteasome-mediated degradation. While MuV V protein targeting of STAT1 is generally accepted as a means of limiting innate antiviral responses, the consequence of V protein targeting of STAT3 is less clear. Further, since the MuV V protein targets both STAT1 and STAT3, specifically investigating viral antagonism of STAT3 targeting is challenging. However, a previous study reported that a single amino acid substitution in the ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2026-05-04T08:56:20.24Z","creation":"2020-05-21T23:54:24Z"},"accession":"S-EPMC6893744","cross_references":{"pubmed":["31683999"],"doi":["10.3390/v11111016"]}}