biostudies-literatureUnknown11(11)Malik TMumps virus (MuV) is a neurotropic non-segmented, negative-stranded, enveloped RNA virus in the <i>Paramyxovirus</i> family. The 15.4 kb genome encodes seven genes, including the V/P, which encodes, among other proteins, the V protein. The MuV V protein has been shown to target the cellular signal transducer and activator of transcription proteins STAT1 and STAT3 for proteasome-mediated degradation. While MuV V protein targeting of STAT1 is generally accepted as a means of limiting innate antiviral responses, the consequence of V protein targeting of STAT3 is less clear. Further, since the MuV V protein targets both STAT1 and STAT3, specifically investigating viral antagonism of STAT3 targeting is challenging. However, a previous study reported that a single amino acid substitution in the VirusesE1016https://www.ebi.ac.uk/biostudies/studies/S-EPMC6893744biostudies-literatureA Single Point Mutation in the Mumps V Protein Alters Targeting of the Cellular STAT Pathways Resulting in Virus Attenuation.PMC6893744Bosma TMalik TNgo LRubin SfalseA Single Point Mutation in the Mumps V Protein Alters Targeting of the Cellular STAT Pathways Resulting in Virus Attenuation.Mumps virus (MuV) is a neurotropic non-segmented, negative-stranded, enveloped RNA virus in the <i>Paramyxovirus</i> family. The 15.4 kb genome encodes seven genes, including the V/P, which encodes, among other proteins, the V protein. The MuV V protein has been shown to target the cellular signal transducer and activator of transcription proteins STAT1 and STAT3 for proteasome-mediated degradation. While MuV V protein targeting of STAT1 is generally accepted as a means of limiting innate antiviral responses, the consequence of V protein targeting of STAT3 is less clear. Further, since the MuV V protein targets both STAT1 and STAT3, specifically investigating viral antagonism of STAT3 targeting is challenging. However, a previous study reported that a single amino acid substitution in the 2019-01-01T00:00:00Z2019 Nov2026-05-04T08:56:20.24Z2020-05-21T23:54:24ZS-EPMC68937443168399910.3390/v11111016