{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(12)"],"submitter":["Han EC"],"pubmed_abstract":["Among the main bacteria implicated in the pathology of periodontal disease, <i>Aggregatibacter actinomycetemcomitans</i> (<i>Aa</i>) is well known for causing loss of periodontal attachment and systemic disease. Recent studies have suggested that secreted extracellular RNAs (exRNAs) from several bacteria may be important in periodontitis, although their role is unclear. Emerging evidence indicates that exRNAs circulate in nanosized bilayered and membranous extracellular vesicles (EVs) known as outer membrane vesicles (OMVs) in gram-negative bacteria. In this study, we analyzed the small RNA expression profiles in activated human macrophage-like cells (U937) infected with OMVs from <i>Aa</i> and investigated whether these cells can harbor exRNAs of bacterial origin that have been loaded int"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pagination":["13412-13422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6894046"],"repository":["biostudies-literature"],"pubmed_title":["Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF-α production in human macrophages and cross the blood-brain barrier in mice."],"pmcid":["PMC6894046"],"pubmed_authors":["Choi SY","Park JW","Lee Y","Lee HJ","Hong SH","Han EC"],"additional_accession":[]},"is_claimable":false,"name":"Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF-α production in human macrophages and cross the blood-brain barrier in mice.","description":"Among the main bacteria implicated in the pathology of periodontal disease, <i>Aggregatibacter actinomycetemcomitans</i> (<i>Aa</i>) is well known for causing loss of periodontal attachment and systemic disease. Recent studies have suggested that secreted extracellular RNAs (exRNAs) from several bacteria may be important in periodontitis, although their role is unclear. Emerging evidence indicates that exRNAs circulate in nanosized bilayered and membranous extracellular vesicles (EVs) known as outer membrane vesicles (OMVs) in gram-negative bacteria. In this study, we analyzed the small RNA expression profiles in activated human macrophage-like cells (U937) infected with OMVs from <i>Aa</i> and investigated whether these cells can harbor exRNAs of bacterial origin that have been loaded int","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2026-05-01T01:22:25.506Z","creation":"2020-09-23T07:01:51Z"},"accession":"S-EPMC6894046","cross_references":{"pubmed":["31545910"],"doi":["10.1096/fj.201901575R","10.1096/fj.201901575r"]}}