{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lei X"],"funding":["NIDA NIH HHS","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","NIMH NIH HHS","NINDS NIH HHS","National Institutes of Health"],"pagination":["14734-14747"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6894063"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(12)"],"pubmed_abstract":["Cytokines and chemokines play diverse roles in different organ systems. Family with sequence similarity 19, member A1-5 (FAM19A1-A5; also known as TAFA1-5) is a group of conserved chemokine-like proteins enriched in the CNS of mice and humans. Their functions are only beginning to emerge. Here, we show that the expression of <i>Fam19a1-a5</i> in different mouse brain regions are induced or suppressed by unfed and refed states. The striking nutritional regulation of <i>Fam19a</i> family members in the brain suggests a potential central role in regulating metabolism. Using a knockout (KO) mouse model, we show that loss of FAM19A1 results in sexually dimorphic phenotypes. In male mice, FAM19A1 deficiency alters food intake patterns during the light and dark cycle. <i>Fam19a1</i> KO mice are h"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors."],"pmcid":["PMC6894063"],"funding_grant_id":["R01 DA041208","T32 NS091018","R01 DK084171","DK084171","R01 MH083728"],"pubmed_authors":["Liu L","Dong X","Lei X","Cisternas P","Wong GW","Lay M","Martinelli DC","Karuppagounder SS","Aja S","Pletnikov MV","Terrillion CE"],"additional_accession":[]},"is_claimable":false,"name":"FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors.","description":"Cytokines and chemokines play diverse roles in different organ systems. Family with sequence similarity 19, member A1-5 (FAM19A1-A5; also known as TAFA1-5) is a group of conserved chemokine-like proteins enriched in the CNS of mice and humans. Their functions are only beginning to emerge. Here, we show that the expression of <i>Fam19a1-a5</i> in different mouse brain regions are induced or suppressed by unfed and refed states. The striking nutritional regulation of <i>Fam19a</i> family members in the brain suggests a potential central role in regulating metabolism. Using a knockout (KO) mouse model, we show that loss of FAM19A1 results in sexually dimorphic phenotypes. In male mice, FAM19A1 deficiency alters food intake patterns during the light and dark cycle. <i>Fam19a1</i> KO mice are h","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-04-19T04:31:09.054Z","creation":"2021-02-20T00:24:08Z"},"accession":"S-EPMC6894063","cross_references":{"pubmed":["31689372"],"doi":["10.1096/fj.201901232RR","10.1096/fj.201901232rr"]}}