{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(12)"],"submitter":["Graves JP"],"pubmed_abstract":["Inflammatory stimuli, such as bacterial LPS, alter the expression of many cytochromes P450. CYP2C and CYP2J subfamily members actively metabolize fatty acids to bioactive eicosanoids, which exhibit potent anti-inflammatory effects. Herein, we examined mRNA levels of the 15 mouse <i>Cyp2c</i> and 7 mouse <i>Cyp2j</i> isoforms in liver, kidney, duodenum, and brain over a 96-h time course of LPS-induced inflammation and resolution. Plasma and liver eicosanoid levels were also measured by liquid chromatography with tandem mass spectrometry. Expression changes in <i>Cyp2c</i> and <i>Cyp2j</i> isoforms were both isoform and tissue specific. Total liver <i>Cyp2c</i> and <i>Cyp2j</i> mRNA content was reduced by 80% 24 h after LPS but recovered to baseline levels by 96 h. Total <i>Cyp2c</i> and <i>"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pagination":["14784-14797"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6894073"],"repository":["biostudies-literature"],"pubmed_title":["Expression of <i>Cyp2c</i>/<i>Cyp2j</i> subfamily members and oxylipin levels during LPS-induced inflammation and resolution in mice."],"pmcid":["PMC6894073"],"pubmed_authors":["Li H","Zeldin DC","Graves JP","Lih FB","Edin ML","Duval C","Bradbury JA","Gruzdev A"],"additional_accession":[]},"is_claimable":false,"name":"Expression of <i>Cyp2c</i>/<i>Cyp2j</i> subfamily members and oxylipin levels during LPS-induced inflammation and resolution in mice.","description":"Inflammatory stimuli, such as bacterial LPS, alter the expression of many cytochromes P450. CYP2C and CYP2J subfamily members actively metabolize fatty acids to bioactive eicosanoids, which exhibit potent anti-inflammatory effects. Herein, we examined mRNA levels of the 15 mouse <i>Cyp2c</i> and 7 mouse <i>Cyp2j</i> isoforms in liver, kidney, duodenum, and brain over a 96-h time course of LPS-induced inflammation and resolution. Plasma and liver eicosanoid levels were also measured by liquid chromatography with tandem mass spectrometry. Expression changes in <i>Cyp2c</i> and <i>Cyp2j</i> isoforms were both isoform and tissue specific. Total liver <i>Cyp2c</i> and <i>Cyp2j</i> mRNA content was reduced by 80% 24 h after LPS but recovered to baseline levels by 96 h. Total <i>Cyp2c</i> and <i>","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-05-18T11:51:10.958Z","creation":"2025-05-18T11:51:10.958Z"},"accession":"S-EPMC6894073","cross_references":{"pubmed":["31690125"],"doi":["10.1096/fj.201901872R","10.1096/fj.201901872r"]}}