{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hofer DC"],"funding":["Austrian Science Fund FWF"],"pagination":["13808-13824"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6894082"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(12)"],"pubmed_abstract":["<i>N</i>-acetylaspartate (NAA) is synthesized by aspartate <i>N</i>-acetyltransferase (gene: <i>Nat8l</i>) from acetyl-coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues remained elusive. Therefore, we characterized the metabolic phenotype of knockout (ko) and adipose tissue-specific (ako) <i>Nat8l</i>-ko mice as well as NAA-supplemented mice on various diets. We identified an important role of NAA availability in the brain during adolescence, as 75% of <i>Nat8l</i>-ko mice died on fat-free diet (FFD) after weaning but could be rescued by NAA supplementation. In adult life, NAA deficiency promotes a beneficial metabolic phenotype, as <i>Nat8l</i>-ko and <i>Nat8l</i>-ako mice showed red"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["<i>N</i>-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health."],"pmcid":["PMC6894082"],"funding_grant_id":["W 1226","DK‐MCD W1226","P24143","J 4205","P27070","P27108"],"pubmed_authors":["Bogner-Strauss JG","Kon K","Eisenberg T","Zirkovits G","Huber K","Zoughbi WA","Schoiswohl G","Schreiber R","Kratky D","Trausinger G","Magnes C","Pessentheiner AR","Hoefler G","Uno K","Graier WF","Sedej S","Pelzmann HJ","Hofer DC","Auwerx J","Eckhardt M","Nitta A","Xia W","Abdellatif M","Madreiter-Sokolowski CT","Sasahara M","Miyazaki T","Tsuneki H","Pendl T","Sasaoka T"],"additional_accession":[]},"is_claimable":false,"name":"<i>N</i>-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health.","description":"<i>N</i>-acetylaspartate (NAA) is synthesized by aspartate <i>N</i>-acetyltransferase (gene: <i>Nat8l</i>) from acetyl-coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues remained elusive. Therefore, we characterized the metabolic phenotype of knockout (ko) and adipose tissue-specific (ako) <i>Nat8l</i>-ko mice as well as NAA-supplemented mice on various diets. We identified an important role of NAA availability in the brain during adolescence, as 75% of <i>Nat8l</i>-ko mice died on fat-free diet (FFD) after weaning but could be rescued by NAA supplementation. In adult life, NAA deficiency promotes a beneficial metabolic phenotype, as <i>Nat8l</i>-ko and <i>Nat8l</i>-ako mice showed red","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-04-04T21:03:07.362Z","creation":"2020-05-21T21:36:24Z"},"accession":"S-EPMC6894082","cross_references":{"pubmed":["31638418"],"doi":["10.1096/fj.201801323R"]}}