{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Chniguir A"],"pubmed_abstract":["Eugenol is a polyphenol extracted from Syzygium aromaticum essential oil. It is known to have anti-inflammatory and chemoprotective properties as well as a potent anti-oxidant activity due the presence of its phenolic group. In this study, we examined the effects of eugenol on neutrophil superoxide production, a key process involved in innate immunity and inflammation. Superoxide anion generationin human neutrophils was measured by cytochrome c reduction assay. Western blotting was used to analyze the phosphorylation of, p47phox, MAPKinases (p38 and ERK1/2), MEK1/2 and Raf, key proteins involved in the activation of NADPH oxidase. Pretreatment of neutrophils by increasing concentrations (2.5 µg/mL-20 µg/mL) of eugenol for 30 min, inhibited significantly (p < 0.001) superoxide anion generat"],"journal":["Scientific reports"],"pagination":["18540"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6898361"],"repository":["biostudies-literature"],"pubmed_title":["Eugenol prevents fMLF-induced superoxide anion production in human neutrophils by inhibiting ERK1/2 signaling pathway and p47phox phosphorylation."],"pmcid":["PMC6898361"],"pubmed_authors":["Chniguir A","Bachoual R","El-Benna J","Liu D","Dang PM","Pintard C"],"additional_accession":[]},"is_claimable":false,"name":"Eugenol prevents fMLF-induced superoxide anion production in human neutrophils by inhibiting ERK1/2 signaling pathway and p47phox phosphorylation.","description":"Eugenol is a polyphenol extracted from Syzygium aromaticum essential oil. It is known to have anti-inflammatory and chemoprotective properties as well as a potent anti-oxidant activity due the presence of its phenolic group. In this study, we examined the effects of eugenol on neutrophil superoxide production, a key process involved in innate immunity and inflammation. Superoxide anion generationin human neutrophils was measured by cytochrome c reduction assay. Western blotting was used to analyze the phosphorylation of, p47phox, MAPKinases (p38 and ERK1/2), MEK1/2 and Raf, key proteins involved in the activation of NADPH oxidase. Pretreatment of neutrophils by increasing concentrations (2.5 µg/mL-20 µg/mL) of eugenol for 30 min, inhibited significantly (p < 0.001) superoxide anion generat","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-05-31T23:01:43.83Z","creation":"2025-05-31T23:01:43.83Z"},"accession":"S-EPMC6898361","cross_references":{"pubmed":["31811262"],"doi":["10.1038/s41598-019-55043-8"]}}