{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":47,"searchCount":0},"additional":{"submitter":["Bortz DM"],"funding":["NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health"],"pagination":["2186-2194"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6898642"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(13)"],"pubmed_abstract":["Cognitive flexibility deficits are one of the most pervasive symptoms across psychiatric disorders, making continued investigation of the circuitry underlying this function a top priority. Medial septum (MS) lesions lead to perseverative, inflexible-type behavior; however, a role for this region in cognitive flexibility circuitry has never been examined. We activated the MS (DREADDs) and measured performance in a T-maze spatial reversal learning task in male Sprague-Dawley rats. Systemic activation of the MS (CNO) significantly decreased both trials to perform a reversal and entries into the previously baited arm. Intra-ventral subiculum CNO enhanced reversal learning in the same manner as systemic CNO and also significantly increased ventral tegmental area and decreased substantia nigra dopamine neuron population activity. Finally, co-injection of the D1 antagonist SCH23390 with CNO prevented the enhanced reversal learning performance seen in the previous two experiments. Taken together, these data suggest a key role for the MS in cognitive flexibility, and suggest that MS-mediated changes in midbrain dopamine neuron population activity could be one mechanism by which this occurs."],"journal":["Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"],"pubmed_title":["The medial septum enhances reversal learning via opposing actions on ventral tegmental area and substantia nigra dopamine neurons."],"pmcid":["PMC6898642"],"funding_grant_id":["1F32MH115550","F32 MH115550","MH057440-11"],"pubmed_authors":["Gazo KL","Grace AA","Bortz DM"],"view_count":["47"],"additional_accession":[]},"is_claimable":false,"name":"The medial septum enhances reversal learning via opposing actions on ventral tegmental area and substantia nigra dopamine neurons.","description":"Cognitive flexibility deficits are one of the most pervasive symptoms across psychiatric disorders, making continued investigation of the circuitry underlying this function a top priority. Medial septum (MS) lesions lead to perseverative, inflexible-type behavior; however, a role for this region in cognitive flexibility circuitry has never been examined. We activated the MS (DREADDs) and measured performance in a T-maze spatial reversal learning task in male Sprague-Dawley rats. Systemic activation of the MS (CNO) significantly decreased both trials to perform a reversal and entries into the previously baited arm. Intra-ventral subiculum CNO enhanced reversal learning in the same manner as systemic CNO and also significantly increased ventral tegmental area and decreased substantia nigra dopamine neuron population activity. Finally, co-injection of the D1 antagonist SCH23390 with CNO prevented the enhanced reversal learning performance seen in the previous two experiments. Taken together, these data suggest a key role for the MS in cognitive flexibility, and suggest that MS-mediated changes in midbrain dopamine neuron population activity could be one mechanism by which this occurs.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2024-11-07T13:16:07.062Z","creation":"2021-02-20T02:11:07Z"},"accession":"S-EPMC6898642","cross_references":{"pubmed":["31261368"],"doi":["10.1038/s41386-019-0453-1"]}}