biostudies-literatureUnknown8(21)Chesnaye NCBackground People with reduced glomerular filtration rate (GFR) often have elevated cardiac troponin T (cTnT) levels. It remains unclear how cTnT levels develop over time in those with chronic kidney disease (CKD). The aim of this study was to prospectively study the association between cTnT and GFR over time in older advanced-stage CKD patients not on dialysis. Methods and Results The EQUAL (European Quality Study) study is an observational prospective cohort study in stage 4 to 5 CKD patients aged ≥65 years not on dialysis (incident estimated GFR, <20 mL/min/1.73 m²). The EQUAL cohort used for the purpose of this study includes 171 patients followed in Sweden between April 2012 and December 2018. We used linear mixed models, adjusted for important groups of confounders, to investigate thJournal of the American Heart Associatione013091https://www.ebi.ac.uk/biostudies/studies/S-EPMC6898818biostudies-literatureAssociation Between Renal Function and Troponin T Over Time in Stable Chronic Kidney Disease Patients.PMC6898818Russo DTognarelli GChesnaye NCPozzi CMotta DMcNally HCiurlino DGaillard CNeumeier KMcKeever AGlowski DStephan TWanner CBaragetti IMalaguti MRoderick PJager KJKooman JMagnano MSchulz PRanghino ASirico MLNavjee SCappellaio FCicchetti TLeimbach THeimburger OFerraro ANigro RMcGlynn DHahn KMele ABahner UUllah ANowanska KNaujoks HGambaro GRothele JDurlik MBoero RRenker STorp AStucchi ABarany PRoy GTurner JPerras BStendahl MManan SWong JDe Simone WO'Toole CSchrander AAcampora PMangano SZullo CMarx CIchtiaris PRogland BTsalouichos ACosaro ACockwell PKalra PBlom ALMusiala AMazur JBoom HRaasveld MEijgenraam JWTorino CFrischmuth ND'alessandro CBlaser Cvan Diepen MKashioulis PEvans MOlczyk EMaffei SDekker FWVervloet MBoots JMurtagh HSchlee ISchlee HBorrelli SPani AMiskowiec-Wisniewska IWeinreich TWilkinson LSundelin FKrieter DSavoldi SSagliocca ANieszporek TAntonio BStovesand TJones KPostorino MEmde CToscano GWoodman ARappa TEQUAL Study Investigators<xref ref-type="author-note" rid="jah34480-note-0002">^†</xref>Banda JSummersgill CMasri-Senghor HBeerenhout CGeddes CRotmans JVerburgh CFerraresi MBertoli SSiegert CBlouin KSands DWilcox JJensen UAnsali FIorio BRDGesualdo LDrechsler CCaloro GSchmidt-Gurtler HScarpioni RGrontoft KCProvenzano MSvensson MBergamo DDe Blasio Avan Dam BWeetman MAugustyniak-Bartosik HCrosbie SPalm SCasar SHoogeveen EBiancone LMaxia SBonforte GDi Bari MJoinson MDelrieux SMatthews MHeidenreich SKuan YBiribauer SGiacchino FDutton MRayner HBigatti GPondel JAbaterusso CSeeger WDattolo PSchmiedeke Tvan Buren MVogt LWuttke NMason PIwig BAign SBeige JRicardi MVigotti FMarinangeli GManitius JPalmieri NCaskey FPorto GHaydock LSajith RHarron CPizzarelli FHirst GBleakley Nvan Esch SAlessandra BPalazzo VVargas DConte GSchneider AConte FKirste PCupisti AFavaro ECirillo PMagin HHopf MLaudato MCapizzi IMalandra RJanmaat CGreco GSzummer KPignataro AAlmquist TBlankestijn PLeurs POldrizzi LNaticchia AWelander GMelander SSicoli RJedrzejak KBoorsma SAydin ZCabiddu GVoskamp PRosso GDJonsson AEQUAL Study Investigators †Konings CUhlin FDimeny EAnding-Rost KSchramm LPiccoli GBarrett CSchattel SNowak LFumagalli GPlaten EMathavakkannan SSchwedler SMurrone PHeleniak ZCarmody MCianciotta FSzymczak MCapasso GIrmler EKing HSomma CSzymczak AMcLaren BWallquist CBerdeprado JHoorn EChapman SDorota SRoser SFuchs DMorgan NHernandez IBBrown STickle SfalseAssociation Between Renal Function and Troponin T Over Time in Stable Chronic Kidney Disease Patients.Background People with reduced glomerular filtration rate (GFR) often have elevated cardiac troponin T (cTnT) levels. It remains unclear how cTnT levels develop over time in those with chronic kidney disease (CKD). The aim of this study was to prospectively study the association between cTnT and GFR over time in older advanced-stage CKD patients not on dialysis. Methods and Results The EQUAL (European Quality Study) study is an observational prospective cohort study in stage 4 to 5 CKD patients aged ≥65 years not on dialysis (incident estimated GFR, <20 mL/min/1.73 m²). The EQUAL cohort used for the purpose of this study includes 171 patients followed in Sweden between April 2012 and December 2018. We used linear mixed models, adjusted for important groups of confounders, to investigate th2019-01-01T00:00:00Z2019 Nov2025-04-26T15:48:12.479Z2025-04-06T14:57:47.601ZS-EPMC68988183166206810.1161/JAHA.119.013091