{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Leong JY"],"funding":["BMRC","National Medical Research Council","Duke-NUS, A*STAR BMRC"],"pagination":["1712-1721"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6900250"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["78(12)"],"pubmed_abstract":["<h4>Objectives</h4>Biologics treatment with antitumour necrosis factor alpha (TNFα) is efficacious in patients with juvenile idiopathic arthritis (JIA). Despite displaying clinical inactivity during treatment, many patients will flare on cessation of therapy. The inability to definitively discriminate patients who will relapse or continue to remain in remission after therapy withdrawal is currently a major unmet medical need. CD4 T cells have been implicated in active disease, yet how they contribute to disease persistence despite treatment is unknown.<h4>Methods</h4>We interrogated the circulatory reservoir of CD4<sup>+</sup> immune subsets at the single-cell resolution with mass cytometry (cytometry by time of flight) of patients with JIA (n=20) who displayed continuous clinical inactivi"],"journal":["Annals of the rheumatic diseases"],"pubmed_title":["Immunome perturbation is present in patients with juvenile idiopathic arthritis who are in remission and will relapse upon anti-TNFα withdrawal."],"pmcid":["PMC6900250"],"funding_grant_id":["MOHIAFCAT2/0001/2014","NMRC MOHIAFCAT1-6003","SPF2014/005","TCR15Jun006","IAF311020","NMRC/STaR/020/2013","MH 095:003\\016-0002","NMRC/MOHIAFCAT2/2/08","NMRC/CIRG/1460/2016"],"pubmed_authors":["Nur Hazirah S","Cassidy EA","Anne Eberhard B","Nocton JJ","Mehta J","Williams CB","Taylor J","Edelheit BS","Gottlieb BS","Yeo JG","Onel K","Huang B","Zemel LS","Ting TV","Chen P","Giannini EH","Chen C","Ally F","Weiss JE","Haines KA","Leong JY","Kietz D","Morris PW","Wagner-Weiner L","Johnson AL","Kimura Y","Passo MH","Arkachaisri T","Grom AA","Verbsky JW","Jung LK","Beukelman T","Schikler K","Brunner HI","Huggins JL","Pediatric Rheumatology Collaborative Study Group","Lovell DJ","Vogler LB","Spalding SJ","Ede KC","Tesher MS","Rouster-Stevens KA","Dare JA","Cron RQ","Bathi LDT","Albani S","Li SC","Olson JC","Costanzo DM","Chua C","Lee ESC","Pan L","Lai L","Lovell D","Griffin TA","Shishov M","Poh SL"],"additional_accession":[]},"is_claimable":false,"name":"Immunome perturbation is present in patients with juvenile idiopathic arthritis who are in remission and will relapse upon anti-TNFα withdrawal.","description":"<h4>Objectives</h4>Biologics treatment with antitumour necrosis factor alpha (TNFα) is efficacious in patients with juvenile idiopathic arthritis (JIA). Despite displaying clinical inactivity during treatment, many patients will flare on cessation of therapy. The inability to definitively discriminate patients who will relapse or continue to remain in remission after therapy withdrawal is currently a major unmet medical need. CD4 T cells have been implicated in active disease, yet how they contribute to disease persistence despite treatment is unknown.<h4>Methods</h4>We interrogated the circulatory reservoir of CD4<sup>+</sup> immune subsets at the single-cell resolution with mass cytometry (cytometry by time of flight) of patients with JIA (n=20) who displayed continuous clinical inactivi","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2026-06-12T05:41:32.283Z","creation":"2020-05-22T00:09:57Z"},"accession":"S-EPMC6900250","cross_references":{"pubmed":["31540934"],"doi":["10.1136/annrheumdis-2019-216059"]}}