biostudies-literatureOhrbach RNIDCR NIH HHSNational Institutes of Health145-158https://www.ebi.ac.uk/biostudies/studies/S-EPMC6901728biostudies-literatureUnknown24(1)<h4>Background</h4>Multiple risk factors predict temporomandibular disorders (TMD) onset, but temporal changes in risk factors and their contribution to risk of TMD have not been evaluated. The study aims were to (a) describe changes occurring in premorbid TMD risk factors when re-measured at TMD onset and 6 months later, and (b) determine if measures of change improve accuracy in predicting TMD incidence compared to premorbid measures alone.<h4>Methods</h4>In this observational prospective cohort study at four university research clinics, 3,258 community-based, 18- to 44-year-olds without TMD were enrolled. During the 3-year median follow-up, 260 incident cases of first-onset TMD were identified, and 196 TMD-free subjects were selected as matched controls. Six-months later, 147 of 260 incEuropean journal of pain (London, England)Premorbid and concurrent predictors of TMD onset and persistence.PMC6901728U01 DE017018U01DE017018Ohrbach RBair ERathnayaka NGreenspan JDMaixner WSlade GDFillingim RBDiatchenko LfalsePremorbid and concurrent predictors of TMD onset and persistence.<h4>Background</h4>Multiple risk factors predict temporomandibular disorders (TMD) onset, but temporal changes in risk factors and their contribution to risk of TMD have not been evaluated. The study aims were to (a) describe changes occurring in premorbid TMD risk factors when re-measured at TMD onset and 6 months later, and (b) determine if measures of change improve accuracy in predicting TMD incidence compared to premorbid measures alone.<h4>Methods</h4>In this observational prospective cohort study at four university research clinics, 3,258 community-based, 18- to 44-year-olds without TMD were enrolled. During the 3-year median follow-up, 260 incident cases of first-onset TMD were identified, and 196 TMD-free subjects were selected as matched controls. Six-months later, 147 of 260 inc2020-01-01T00:00:00Z2020 Jan2025-04-19T18:03:00.323Z2021-02-20T17:14:10ZS-EPMC69017283142100910.1002/ejp.1472