{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(11)"],"submitter":["Swayden M"],"pubmed_abstract":["The dismal prognosis of pancreatic ductal adenocarcinoma (PDAC) is mainly due to its rapidly acquired resistance to all conventional treatments. Despite drug-specific mechanisms of resistance, none explains how these cells resist the stress induced by any kind of anticancer treatment. Activation of stress-response pathways relies on the post-translational modifications (PTMs) of involved proteins. Among all PTMs, those mediated by the ubiquitin family of proteins play a central role. Our aim was to identify alterations of ubiquitination, neddylation, and sumoylation associated with the multiresistant phenotype and demonstrate their implications in the survival of PDAC cells undergoing treatment. This approach pointed at an alteration of promyelocytic leukemia (PML) protein sumoylation asso"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pagination":["12447-12463"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6902661"],"repository":["biostudies-literature"],"pubmed_title":["PML hyposumoylation is responsible for the resistance of pancreatic cancer."],"pmcid":["PMC6902661"],"pubmed_authors":["Hannouche L","Alzeeb G","Berthois Y","Dusetti N","Gayet O","Silvy F","Iovanna JL","Camoin L","Vachon H","Soubeyran P","Bigonnet M","Roques J","Masoud R","Carrier A","Audebert S","Swayden M"],"additional_accession":[]},"is_claimable":false,"name":"PML hyposumoylation is responsible for the resistance of pancreatic cancer.","description":"The dismal prognosis of pancreatic ductal adenocarcinoma (PDAC) is mainly due to its rapidly acquired resistance to all conventional treatments. Despite drug-specific mechanisms of resistance, none explains how these cells resist the stress induced by any kind of anticancer treatment. Activation of stress-response pathways relies on the post-translational modifications (PTMs) of involved proteins. Among all PTMs, those mediated by the ubiquitin family of proteins play a central role. Our aim was to identify alterations of ubiquitination, neddylation, and sumoylation associated with the multiresistant phenotype and demonstrate their implications in the survival of PDAC cells undergoing treatment. This approach pointed at an alteration of promyelocytic leukemia (PML) protein sumoylation asso","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2026-05-02T15:03:29.413Z","creation":"2025-07-26T03:06:05.382Z"},"accession":"S-EPMC6902661","cross_references":{"pubmed":["31557059"],"doi":["10.1096/fj.201901091R","10.1096/fj.201901091r"]}}