{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang T"],"funding":["National Natural Science Foundation of China"],"pagination":["11776-11790"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6902687"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(11)"],"pubmed_abstract":["Blood-retinal barrier (BRB) breakdown is a typical event in the early stage of diabetic retinopathy (DR). This study aims to elucidate the protection of erianin, a natural compound isolated from <i>Dendrobium chrysotoxum</i> Lindl, against DR development. Erianin alleviated BRB breakdown and rescued the reduced claudin1 and occludin expression in retinas from streptozotocin-induced diabetic mice. Erianin reduced microglial activation, ERK1/2 phosphorylation, NF-κB transcriptional activation, and the elevated TNF-α expression both <i>in vitro</i> and <i>in vivo</i>. ERK1/2 inhibitor U0126 abrogated NF-κB activation in d-glucose-treated BV2 cells. Erianin reduced cellular glucose uptake, and molecular docking analysis indicated the potential interaction of erianin with glucose transporter (G"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["Erianin alleviates diabetic retinopathy by reducing retinal inflammation initiated by microglial cells <i>via</i> inhibiting hyperglycemia-mediated ERK1/2-NF-κB signaling pathway."],"pmcid":["PMC6902687"],"funding_grant_id":["81573679","81322053","81173517"],"pubmed_authors":["Zhang T","Chen K","Ouyang H","Mei X","Ji L","Yu Z","Wang Z","Lu B"],"additional_accession":[]},"is_claimable":false,"name":"Erianin alleviates diabetic retinopathy by reducing retinal inflammation initiated by microglial cells <i>via</i> inhibiting hyperglycemia-mediated ERK1/2-NF-κB signaling pathway.","description":"Blood-retinal barrier (BRB) breakdown is a typical event in the early stage of diabetic retinopathy (DR). This study aims to elucidate the protection of erianin, a natural compound isolated from <i>Dendrobium chrysotoxum</i> Lindl, against DR development. Erianin alleviated BRB breakdown and rescued the reduced claudin1 and occludin expression in retinas from streptozotocin-induced diabetic mice. Erianin reduced microglial activation, ERK1/2 phosphorylation, NF-κB transcriptional activation, and the elevated TNF-α expression both <i>in vitro</i> and <i>in vivo</i>. ERK1/2 inhibitor U0126 abrogated NF-κB activation in d-glucose-treated BV2 cells. Erianin reduced cellular glucose uptake, and molecular docking analysis indicated the potential interaction of erianin with glucose transporter (G","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2026-05-04T03:43:57.878Z","creation":"2020-11-19T13:35:31Z"},"accession":"S-EPMC6902687","cross_references":{"pubmed":["31365278"],"doi":["10.1096/fj.201802614RRR","10.1096/fj.201802614rrr"]}}