{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(6)"],"submitter":["Kochlik B"],"pubmed_abstract":["<h4>Background</h4>A poor fat-soluble micronutrient (FMN) and a high oxidative stress status are associated with frailty. Our aim was to determine the cross-sectional association of FMNs and oxidative stress biomarkers [protein carbonyls (PrCarb) and 3-nitrotyrosine] with the frailty status in participants older than 65 years.<h4>Methods</h4>Plasma levels of vitamins A (retinol), D<sub>3</sub> , E (α-tocopherol and γ-tocopherol) and carotenoids (α-carotene and β-carotene, lycopene, lutein/zeaxanthin, and β-cryptoxanthin), PrCarb, and 3-nitrotyrosine were measured in 1450 individuals of the FRAILOMIC initiative. Participants were classified into robust, pre-frail, and frail using Fried's frailty criteria. Associations between biomarkers and frailty status were assessed by general linear and"],"journal":["Journal of cachexia, sarcopenia and muscle"],"pagination":["1339-1346"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6903435"],"repository":["biostudies-literature"],"pubmed_title":["Associations of fat-soluble micronutrients and redox biomarkers with frailty status in the FRAILOMIC initiative."],"pmcid":["PMC6903435"],"pubmed_authors":["Pilleron S","Gomez-Cabrero D","Grune T","Kochlik B","Peres K","Garcia Garcia FJ","Bandinelli S","Rodriguez-Manas L","Weber D","Feart C","Stuetz W"],"additional_accession":[]},"is_claimable":false,"name":"Associations of fat-soluble micronutrients and redox biomarkers with frailty status in the FRAILOMIC initiative.","description":"<h4>Background</h4>A poor fat-soluble micronutrient (FMN) and a high oxidative stress status are associated with frailty. Our aim was to determine the cross-sectional association of FMNs and oxidative stress biomarkers [protein carbonyls (PrCarb) and 3-nitrotyrosine] with the frailty status in participants older than 65 years.<h4>Methods</h4>Plasma levels of vitamins A (retinol), D<sub>3</sub> , E (α-tocopherol and γ-tocopherol) and carotenoids (α-carotene and β-carotene, lycopene, lutein/zeaxanthin, and β-cryptoxanthin), PrCarb, and 3-nitrotyrosine were measured in 1450 individuals of the FRAILOMIC initiative. Participants were classified into robust, pre-frail, and frail using Fried's frailty criteria. Associations between biomarkers and frailty status were assessed by general linear and","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-04-26T15:47:46.062Z","creation":"2020-05-21T23:33:40Z"},"accession":"S-EPMC6903435","cross_references":{"pubmed":["31436047"],"doi":["10.1002/jcsm.12479"]}}