biostudies-literatureUnknown10(6)Kochlik B<h4>Background</h4>A poor fat-soluble micronutrient (FMN) and a high oxidative stress status are associated with frailty. Our aim was to determine the cross-sectional association of FMNs and oxidative stress biomarkers [protein carbonyls (PrCarb) and 3-nitrotyrosine] with the frailty status in participants older than 65 years.<h4>Methods</h4>Plasma levels of vitamins A (retinol), D₃ , E (α-tocopherol and γ-tocopherol) and carotenoids (α-carotene and β-carotene, lycopene, lutein/zeaxanthin, and β-cryptoxanthin), PrCarb, and 3-nitrotyrosine were measured in 1450 individuals of the FRAILOMIC initiative. Participants were classified into robust, pre-frail, and frail using Fried's frailty criteria. Associations between biomarkers and frailty status were assessed by general linear andJournal of cachexia, sarcopenia and muscle1339-1346https://www.ebi.ac.uk/biostudies/studies/S-EPMC6903435biostudies-literatureAssociations of fat-soluble micronutrients and redox biomarkers with frailty status in the FRAILOMIC initiative.PMC6903435Pilleron SGomez-Cabrero DGrune TKochlik BPeres KGarcia Garcia FJBandinelli SRodriguez-Manas LWeber DFeart CStuetz WfalseAssociations of fat-soluble micronutrients and redox biomarkers with frailty status in the FRAILOMIC initiative.<h4>Background</h4>A poor fat-soluble micronutrient (FMN) and a high oxidative stress status are associated with frailty. Our aim was to determine the cross-sectional association of FMNs and oxidative stress biomarkers [protein carbonyls (PrCarb) and 3-nitrotyrosine] with the frailty status in participants older than 65 years.<h4>Methods</h4>Plasma levels of vitamins A (retinol), D₃ , E (α-tocopherol and γ-tocopherol) and carotenoids (α-carotene and β-carotene, lycopene, lutein/zeaxanthin, and β-cryptoxanthin), PrCarb, and 3-nitrotyrosine were measured in 1450 individuals of the FRAILOMIC initiative. Participants were classified into robust, pre-frail, and frail using Fried's frailty criteria. Associations between biomarkers and frailty status were assessed by general linear and2019-01-01T00:00:00Z2019 Dec2025-04-26T15:47:46.062Z2020-05-21T23:33:40ZS-EPMC69034353143604710.1002/jcsm.12479