{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sonnenblick A"],"funding":["NCI NIH HHS"],"pagination":["424-432"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6903891"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(2)"],"pubmed_abstract":["In the present study, in order to investigate the role of signal transducer and activator of transcription 3 (STAT3) in estrogen receptor (ER)-positive breast cancer prognosis, we evaluated the phosphorylated STAT3 (p-STAT3) status and investigated its effect on the outcome in a pooled analysis and in a large prospective adjuvant trial. By using the TCGA repository, we developed gene signatures that reflected the level of p-STAT3. Using pooled analysis of the expression data from luminal breast cancer patients, we assessed the effects of the p-STAT3 expression signature on prognosis. We further validated the p-STAT3 prognostic effect using immunohistochemistry (IHC) and immunofluorescence staining of p-STAT3 tissue microarrays from a large randomised prospective trial. Our analysis demonst"],"journal":["International journal of oncology"],"pubmed_title":["p-STAT3 in luminal breast cancer: Integrated RNA-protein pooled analysis and results from the BIG 2-98 phase III trial."],"pmcid":["PMC6903891"],"funding_grant_id":["P30 CA008748"],"pubmed_authors":["Viale G","De Azambuja E","Peretz T","Crown JPA","Daly L","Francis PA","Sotiriou C","Javdan B","Zahavi T","Di Leo A","Fujisawa S","Lieveke A","Piccart MJ","Salmon A","Rouas G","Sonnenblick A","Salgado R","Brohee S","Bromberg JF","Van den Eynden G"],"additional_accession":[]},"is_claimable":false,"name":"p-STAT3 in luminal breast cancer: Integrated RNA-protein pooled analysis and results from the BIG 2-98 phase III trial.","description":"In the present study, in order to investigate the role of signal transducer and activator of transcription 3 (STAT3) in estrogen receptor (ER)-positive breast cancer prognosis, we evaluated the phosphorylated STAT3 (p-STAT3) status and investigated its effect on the outcome in a pooled analysis and in a large prospective adjuvant trial. By using the TCGA repository, we developed gene signatures that reflected the level of p-STAT3. Using pooled analysis of the expression data from luminal breast cancer patients, we assessed the effects of the p-STAT3 expression signature on prognosis. We further validated the p-STAT3 prognostic effect using immunohistochemistry (IHC) and immunofluorescence staining of p-STAT3 tissue microarrays from a large randomised prospective trial. Our analysis demonst","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2025-04-19T19:30:01.237Z","creation":"2020-05-21T22:32:03Z"},"accession":"S-EPMC6903891","cross_references":{"pubmed":["29207087"],"doi":["10.3892/ijo.2017.4212"]}}