{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chauvigne F"],"funding":["Norges Forskningsråd"],"pagination":["462"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6906440"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2"],"pubmed_abstract":["Water channels (aquaporins) were originally discovered in mammals with fourteen subfamilies now identified (AQP0-13). Here we show that a functional Aqp14 subfamily phylogenetically related to AQP4-type channels exists in all vertebrate lineages except hagfishes and eutherian mammals. In contrast to the water-selective classical aquaporins, which have four aromatic-arginine constriction residues, Aqp14 proteins present five non-aromatic constriction residues and facilitate the permeation of water, urea, ammonia, H<sub>2</sub>O<sub>2</sub> and glycerol. Immunocytochemical assays suggest that Aqp14 channels play important osmoregulatory roles in piscine seawater adaptation. Our data indicate that Aqp14 intracellular trafficking is tightly regulated by the vasotocinergic/isotocinergic neurope"],"journal":["Communications biology"],"pubmed_title":["The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter."],"pmcid":["PMC6906440"],"funding_grant_id":["294768/E40","254872/E40"],"pubmed_authors":["Fjelldal PG","Cerda J","Finn RN","Yilmaz O","Chauvigne F","Ferre A"],"additional_accession":[]},"is_claimable":false,"name":"The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter.","description":"Water channels (aquaporins) were originally discovered in mammals with fourteen subfamilies now identified (AQP0-13). Here we show that a functional Aqp14 subfamily phylogenetically related to AQP4-type channels exists in all vertebrate lineages except hagfishes and eutherian mammals. In contrast to the water-selective classical aquaporins, which have four aromatic-arginine constriction residues, Aqp14 proteins present five non-aromatic constriction residues and facilitate the permeation of water, urea, ammonia, H<sub>2</sub>O<sub>2</sub> and glycerol. Immunocytochemical assays suggest that Aqp14 channels play important osmoregulatory roles in piscine seawater adaptation. Our data indicate that Aqp14 intracellular trafficking is tightly regulated by the vasotocinergic/isotocinergic neurope","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-05-01T22:04:13.72Z","creation":"2020-05-21T23:48:52Z"},"accession":"S-EPMC6906440","cross_references":{"pubmed":["31840107"],"doi":["10.1038/s42003-019-0713-y"]}}