biostudies-literatureUnknown134(21)Marx CClinical observations implicate a role of eosinophils in cardiovascular diseases because markers of eosinophil activation are elevated in atherosclerosis and thrombosis. However, their contribution to atherosclerotic plaque formation and arterial thrombosis remains unclear. In these settings, we investigated how eosinophils are recruited and activated through an interplay with platelets. Here, we provide evidence for a central importance of eosinophil-platelet interactions in atherosclerosis and thrombosis. We show that eosinophils support atherosclerotic plaque formation involving enhanced von Willebrand factor exposure on endothelial cells and augmented platelet adhesion. During arterial thrombosis, eosinophils are quickly recruited in an integrin-dependent manner and engage in interactiBlood1859-1872https://www.ebi.ac.uk/biostudies/studies/S-EPMC6908806biostudies-literatureEosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps.PMC6908806Stocker TJNeumann FJMoser MAdriaenssens TStark KPircher JMarx CKilani BStockhausen SDesmet WNovotny JTen Berg JMSalbeck DKupka DJoner MLorenz MPekayvaz KBurgener NGerschlick AHWeckbach LTZellner KRNicolai LfalseEosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps.Clinical observations implicate a role of eosinophils in cardiovascular diseases because markers of eosinophil activation are elevated in atherosclerosis and thrombosis. However, their contribution to atherosclerotic plaque formation and arterial thrombosis remains unclear. In these settings, we investigated how eosinophils are recruited and activated through an interplay with platelets. Here, we provide evidence for a central importance of eosinophil-platelet interactions in atherosclerosis and thrombosis. We show that eosinophils support atherosclerotic plaque formation involving enhanced von Willebrand factor exposure on endothelial cells and augmented platelet adhesion. During arterial thrombosis, eosinophils are quickly recruited in an integrin-dependent manner and engage in interacti2019-01-01T00:00:00Z2019 Nov2026-06-14T05:32:31.351Z2025-04-06T17:20:57.646ZS-EPMC69088063148148210.1182/blood.2019000518