{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhong W"],"funding":["WesternU intramural startup","NCI","NCI NIH HHS","NIH"],"pagination":["104603"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6911829"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["132"],"pubmed_abstract":["Glycogen synthase kinase 3 (GSK-3) is a constitutively active multifunctional serine-threonine kinase which is involved in diverse physiological processes. GSK-3 has been implicated in a wide range of diseases including neurodegeneration, inflammation, diabetes and cancer. GSK-3 is a downstream target for protein kinase B (Akt) which phosphorylates GSK-3 and suppresses its activity. Based upon our preliminary findings, we postulated Akt's involvement in emesis. The aim of this study was to investigate the participation of GSK-3 and the antiemetic potential of two GSK-3 inhibitors (AR-A014418 and SB216763) in the least shrew model of vomiting against fully-effective emetic doses of diverse emetogens, including the nonselective and/or selective agonists of serotonin type 3 (e.g. 5-HT or 2-Me"],"journal":["Neurochemistry international"],"pubmed_title":["The pivotal role of glycogen synthase kinase 3 (GSK-3) in vomiting evoked by specific emetogens in the least shrew (Cryptotis parva)."],"pmcid":["PMC6911829"],"funding_grant_id":["CA207287","1395","R01 CA207287"],"pubmed_authors":["Zhong W","Darmani NA"],"additional_accession":[]},"is_claimable":false,"name":"The pivotal role of glycogen synthase kinase 3 (GSK-3) in vomiting evoked by specific emetogens in the least shrew (Cryptotis parva).","description":"Glycogen synthase kinase 3 (GSK-3) is a constitutively active multifunctional serine-threonine kinase which is involved in diverse physiological processes. GSK-3 has been implicated in a wide range of diseases including neurodegeneration, inflammation, diabetes and cancer. GSK-3 is a downstream target for protein kinase B (Akt) which phosphorylates GSK-3 and suppresses its activity. Based upon our preliminary findings, we postulated Akt's involvement in emesis. The aim of this study was to investigate the participation of GSK-3 and the antiemetic potential of two GSK-3 inhibitors (AR-A014418 and SB216763) in the least shrew model of vomiting against fully-effective emetic doses of diverse emetogens, including the nonselective and/or selective agonists of serotonin type 3 (e.g. 5-HT or 2-Me","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2025-06-01T01:38:14.013Z","creation":"2025-06-01T01:38:14.013Z"},"accession":"S-EPMC6911829","cross_references":{"pubmed":["31738972"],"doi":["10.1016/j.neuint.2019.104603"]}}