{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Conti A"],"funding":["European Commission"],"pagination":["6341545"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6914891"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2019"],"pubmed_abstract":["Low-intensity focused ultrasound (FUS), combined with microbubbles, is able to locally, and noninvasively, open the blood-brain barrier (BBB), allowing nanoparticles to enter the brain. We present here a study on the diffusion process of gadolinium-based MRI contrast agents within the brain extracellular space after ultrasound-induced BBB permeabilization. Three compounds were tested (MultiHance, Gadovist, and Dotarem). We characterized their diffusion through <i>in vivo</i> experimental tests supported by theoretical models. Specifically, by estimation of the free diffusion coefficients from <i>in vitro</i> studies and of apparent diffusion coefficients from <i>in vivo</i> experiments, we have assessed tortuosity in the right striatum of 9 Sprague Dawley rats through a model correctly des"],"journal":["Contrast media & molecular imaging"],"pubmed_title":["Empirical and Theoretical Characterization of the Diffusion Process of Different Gadolinium-Based Nanoparticles within the Brain Tissue after Ultrasound-Induced Permeabilization of the Blood-Brain Barrier."],"pmcid":["PMC6914891"],"funding_grant_id":["600382"],"pubmed_authors":["Lux F","Della Penna S","Meriaux S","Conti A","Tsapis N","Dumont E","Larrat B","Le Bihan D","Magnin R","Gerstenmayer M","Tillement O"],"additional_accession":[]},"is_claimable":false,"name":"Empirical and Theoretical Characterization of the Diffusion Process of Different Gadolinium-Based Nanoparticles within the Brain Tissue after Ultrasound-Induced Permeabilization of the Blood-Brain Barrier.","description":"Low-intensity focused ultrasound (FUS), combined with microbubbles, is able to locally, and noninvasively, open the blood-brain barrier (BBB), allowing nanoparticles to enter the brain. We present here a study on the diffusion process of gadolinium-based MRI contrast agents within the brain extracellular space after ultrasound-induced BBB permeabilization. Three compounds were tested (MultiHance, Gadovist, and Dotarem). We characterized their diffusion through <i>in vivo</i> experimental tests supported by theoretical models. Specifically, by estimation of the free diffusion coefficients from <i>in vitro</i> studies and of apparent diffusion coefficients from <i>in vivo</i> experiments, we have assessed tortuosity in the right striatum of 9 Sprague Dawley rats through a model correctly des","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-18T13:39:01.23Z","creation":"2020-05-21T23:52:27Z"},"accession":"S-EPMC6914891","cross_references":{"pubmed":["31866799"],"doi":["10.1155/2019/6341545"]}}