biostudies-literatureConti AEuropean Commission6341545https://www.ebi.ac.uk/biostudies/studies/S-EPMC6914891biostudies-literatureUnknown2019Low-intensity focused ultrasound (FUS), combined with microbubbles, is able to locally, and noninvasively, open the blood-brain barrier (BBB), allowing nanoparticles to enter the brain. We present here a study on the diffusion process of gadolinium-based MRI contrast agents within the brain extracellular space after ultrasound-induced BBB permeabilization. Three compounds were tested (MultiHance, Gadovist, and Dotarem). We characterized their diffusion through <i>in vivo</i> experimental tests supported by theoretical models. Specifically, by estimation of the free diffusion coefficients from <i>in vitro</i> studies and of apparent diffusion coefficients from <i>in vivo</i> experiments, we have assessed tortuosity in the right striatum of 9 Sprague Dawley rats through a model correctly desContrast media & molecular imagingEmpirical and Theoretical Characterization of the Diffusion Process of Different Gadolinium-Based Nanoparticles within the Brain Tissue after Ultrasound-Induced Permeabilization of the Blood-Brain Barrier.PMC6914891600382Lux FDella Penna SMeriaux SConti ATsapis NDumont ELarrat BLe Bihan DMagnin RGerstenmayer MTillement OfalseEmpirical and Theoretical Characterization of the Diffusion Process of Different Gadolinium-Based Nanoparticles within the Brain Tissue after Ultrasound-Induced Permeabilization of the Blood-Brain Barrier.Low-intensity focused ultrasound (FUS), combined with microbubbles, is able to locally, and noninvasively, open the blood-brain barrier (BBB), allowing nanoparticles to enter the brain. We present here a study on the diffusion process of gadolinium-based MRI contrast agents within the brain extracellular space after ultrasound-induced BBB permeabilization. Three compounds were tested (MultiHance, Gadovist, and Dotarem). We characterized their diffusion through <i>in vivo</i> experimental tests supported by theoretical models. Specifically, by estimation of the free diffusion coefficients from <i>in vitro</i> studies and of apparent diffusion coefficients from <i>in vivo</i> experiments, we have assessed tortuosity in the right striatum of 9 Sprague Dawley rats through a model correctly des2019-01-01T00:00:00Z20192025-04-18T13:39:01.23Z2020-05-21T23:52:27ZS-EPMC69148913186679910.1155/2019/6341545