{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":51,"searchCount":0},"additional":{"submitter":["Plamadeala C"],"funding":["Austrian Research Promotion Agency FFG","Austrian Science Fund FWF","European Program H2020","Interreg Program"],"pagination":["8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6915113"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Biomimetics is the interdisciplinary scientific field focused on the study and imitation of biological systems, with the aim of solving complex technological problems. In this paper, we present a new bio-inspired design for microneedles (MNs) and MN arrays, intended for rapidly coating the MNs with drug/vaccine. The biomimetic approach consists in ornamenting the lateral sides of pyramidal MNs with structures inspired by the external scent efferent systems of some European true bugs, which facilitate a directional liquid transport. To realize these MNs, two-photon polymerization (TPP) technique was used. Liquid coating capabilities of structured and non-structured MNs were compared. Moreover, both in-vivo and ex-vivo skin tests were performed to prove that MNs pierce the skin. We show that the arrays of MNs can be accurately replicated using a micro-moulding technique. We believe this design will be beneficial for the process of drug/vaccine loading onto the needles' surfaces, by making it more efficient and by reducing the drug/vaccine wastage during MN coating process."],"journal":["Biomedical microdevices"],"pubmed_title":["Bio-inspired microneedle design for efficient drug/vaccine coating."],"pmcid":["PMC6915113"],"funding_grant_id":["665337","AUCZ14","853482","W 1250"],"pubmed_authors":["Jacak J","O'Mahony C","Heitz J","Plamadeala C","Hischen F","Buchroithner B","Bocchino A","Baumgartner W","Gosain SR","Puthukodan S","Whelan D"],"view_count":["51"],"additional_accession":[]},"is_claimable":false,"name":"Bio-inspired microneedle design for efficient drug/vaccine coating.","description":"Biomimetics is the interdisciplinary scientific field focused on the study and imitation of biological systems, with the aim of solving complex technological problems. In this paper, we present a new bio-inspired design for microneedles (MNs) and MN arrays, intended for rapidly coating the MNs with drug/vaccine. The biomimetic approach consists in ornamenting the lateral sides of pyramidal MNs with structures inspired by the external scent efferent systems of some European true bugs, which facilitate a directional liquid transport. To realize these MNs, two-photon polymerization (TPP) technique was used. Liquid coating capabilities of structured and non-structured MNs were compared. Moreover, both in-vivo and ex-vivo skin tests were performed to prove that MNs pierce the skin. We show that the arrays of MNs can be accurately replicated using a micro-moulding technique. We believe this design will be beneficial for the process of drug/vaccine loading onto the needles' surfaces, by making it more efficient and by reducing the drug/vaccine wastage during MN coating process.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2024-02-16T04:17:02.507Z","creation":"2020-05-22T14:21:35Z"},"accession":"S-EPMC6915113","cross_references":{"pubmed":["31845066"],"doi":["10.1007/s10544-019-0456-z"]}}