biostudies-literatureNaik YNorwegian Research CouncilMedical Research CouncilNational Institute for Health Research (NIHR)Fuse - funded by British Heart Foundation, Cancer Research UK, Economic and Social Research Council, Medical Research Council and the National Institute for Health Research, under the auspices of the UK Clinical Research CollaborationWellcome Trust1678https://www.ebi.ac.uk/biostudies/studies/S-EPMC6915896biostudies-literatureUnknown19(1)<h4>Background</h4>The social determinants of health have been widely recognised yet there remains a lack of clarity regarding what constitute the macro-economic determinants of health and what can be done to address them. An umbrella review of systematic reviews was conducted to identify the evidence for the health and health inequalities impact of population level macroeconomic factors, strategies, policies and interventions.<h4>Methods</h4>Nine databases were searched for systematic reviews meeting the Database of Abstracts of Reviews of Effects (DARE) criteria using a novel conceptual framework. Studies were assessed for quality using a standardised instrument and a narrative overview of the findings is presented.<h4>Results</h4>The review found a large (n = 62) but low quality systemaBMC public healthGoing upstream - an umbrella review of the macroeconomic determinants of health and health inequalities.PMC6915896[MR/K02325X/1]215654/Z/19/ZNIHR CLAHRC NWC106554/Z/14/ZCL-2018-18-012288638MR/K02325X/1MR/K02325X/1BACF-2015-21-024Black MGopfert ABambra CTillmann TNaik YJayatunga WBarr BBash KRoderick PHillier-Brown FKelly GQuantz DIsmail SABaker PfalseGoing upstream - an umbrella review of the macroeconomic determinants of health and health inequalities.<h4>Background</h4>The social determinants of health have been widely recognised yet there remains a lack of clarity regarding what constitute the macro-economic determinants of health and what can be done to address them. An umbrella review of systematic reviews was conducted to identify the evidence for the health and health inequalities impact of population level macroeconomic factors, strategies, policies and interventions.<h4>Methods</h4>Nine databases were searched for systematic reviews meeting the Database of Abstracts of Reviews of Effects (DARE) criteria using a novel conceptual framework. Studies were assessed for quality using a standardised instrument and a narrative overview of the findings is presented.<h4>Results</h4>The review found a large (n = 62) but low quality systema2019-01-01T00:00:00Z2019 Dec2025-06-01T02:51:34.035Z2020-05-22T01:02:49ZS-EPMC69158963184283510.1186/s12889-019-7895-6