{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sheen MR"],"funding":["NCI NIH HHS","Laura and John Arnold Foundation"],"pagination":["e45120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6917490"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Fiering et al., 2015) that described how we intended to replicate selected experiments from the paper 'Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis' (Goetz et al., 2011). Here we report the results. Primary mouse embryonic fibroblasts (pMEFs) expressing caveolin 1 (Cav1WT) demonstrated increased extracellular matrix remodeling <i>in vitro</i> compared to Cav1 deficient (Cav1KO) pMEFs, similar to the original study (Goetz et al., 2011). <i>In vivo</i>, we found higher levels of intratumoral stroma remodeling, determined by fibronectin fiber orientation, in tumors from cancer cells co-injected with Cav1WT pMEFs compared to cancer cells only o"],"journal":["eLife"],"pubmed_title":["Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis."],"pmcid":["PMC6917490"],"funding_grant_id":["P30 CA023108"],"pubmed_authors":["Reproducibility Project: Cancer Biology","Errington TM","Fields JL","Perfito N","Tsui R","Sheen MR","Northan B","Denis A","Ang LH","Iorns E","Lacoste J","Fiering S"],"additional_accession":[]},"is_claimable":false,"name":"Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis.","description":"As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Fiering et al., 2015) that described how we intended to replicate selected experiments from the paper 'Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis' (Goetz et al., 2011). Here we report the results. Primary mouse embryonic fibroblasts (pMEFs) expressing caveolin 1 (Cav1WT) demonstrated increased extracellular matrix remodeling <i>in vitro</i> compared to Cav1 deficient (Cav1KO) pMEFs, similar to the original study (Goetz et al., 2011). <i>In vivo</i>, we found higher levels of intratumoral stroma remodeling, determined by fibronectin fiber orientation, in tumors from cancer cells co-injected with Cav1WT pMEFs compared to cancer cells only o","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2026-04-14T21:08:31.089Z","creation":"2020-05-22T00:05:02Z"},"accession":"S-EPMC6917490","cross_references":{"pubmed":["31845647"],"doi":["10.7554/eLife.45120"]}}