{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Biancolin AD"],"funding":["Canadian Foundation for Innovation and Ontario Research Fund","Banting and Best Diabetes Centre, University of Toronto","NIDDK NIH HHS","Banting Research Foundation","Medical Research Council","Tier II Canada Research Chair","Ontario Graduate Scholarship and Banting and Best Diabetes Centre, University of Toronto","Wellcome Trust","Canadian Institutes of Health Research","Tier I Canada Research Chair"],"pagination":["124-137"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6920326"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31"],"pubmed_abstract":["<h4>Objectives</h4>The incretin hormone glucagon-like peptide-1 (GLP-1) is secreted from intestinal L-cells upon nutrient intake. While recent evidence has shown that GLP-1 is released in a circadian manner in rats, whether this occurs in mice and if this pattern is regulated by the circadian clock remain to be elucidated. Furthermore, although circadian GLP-1 secretion parallels expression of the core clock gene Bmal1, the link between the two remains largely unknown. Secretagogin (Scgn) is an exocytotic SNARE regulatory protein that demonstrates circadian expression and is essential for insulin secretion from β-cells. The objective of the current study was to establish the necessity of the core clock gene Bmal1 and the SNARE protein SCGN as essential regulators of circadian GLP-1 secreti"],"journal":["Molecular metabolism"],"pubmed_title":["The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1."],"pmcid":["PMC6920326"],"funding_grant_id":["106263/Z/14/Z","MC_UU_12012/3","106262/Z/14/Z","30961","MRC_MC_UU_12012/3","19442","P30 DK036836","MC_UU_12012/5/B","MC_UU_00014/5","MC_UU_00014/3","MC_UU_12012/5"],"pubmed_authors":["Gribble FM","Gil-Lozano M","Mitova E","Doria A","Martchenko A","Reimann F","Adriaenssens AE","Biancolin AD","Gurges P","Brubaker PL","Michalchyshyn E","Mychaleckyj JC","Chalmers JA","Cox BJ"],"additional_accession":[]},"is_claimable":false,"name":"The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1.","description":"<h4>Objectives</h4>The incretin hormone glucagon-like peptide-1 (GLP-1) is secreted from intestinal L-cells upon nutrient intake. While recent evidence has shown that GLP-1 is released in a circadian manner in rats, whether this occurs in mice and if this pattern is regulated by the circadian clock remain to be elucidated. Furthermore, although circadian GLP-1 secretion parallels expression of the core clock gene Bmal1, the link between the two remains largely unknown. Secretagogin (Scgn) is an exocytotic SNARE regulatory protein that demonstrates circadian expression and is essential for insulin secretion from β-cells. The objective of the current study was to establish the necessity of the core clock gene Bmal1 and the SNARE protein SCGN as essential regulators of circadian GLP-1 secreti","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2026-04-15T11:17:30.791Z","creation":"2020-05-22T07:41:18Z"},"accession":"S-EPMC6920326","cross_references":{"pubmed":["31918914"],"doi":["10.1016/j.molmet.2019.11.004"]}}