biostudies-literatureMaruyama SRFundação de Amparo à Pesquisa do Estado de São Paulo53https://www.ebi.ac.uk/biostudies/studies/S-EPMC6920353biostudies-literatureUnknown4Ticks cause massive damage to livestock and vaccines are one sustainable alternative for the acaricide poisons currently heavily used to control infestations. An experimental vaccine adjuvanted with alum and composed by four recombinant salivary antigens mined with reverse vaccinology from a transcriptome of salivary glands from <i>Rhipicephalus microplus</i> ticks was previously shown to present an overall efficacy of 73.2% and cause a significant decrease of tick loads in artificially tick-infested, immunized heifers; this decrease was accompanied by increased levels of antigen-specific IgG1 and IgG2 antibodies, which were boosted during a challenge infestation. In order to gain insights into the systemic effects induced by the vaccine and by the tick challenge we now report the gene expNPJ vaccinesBlood transcriptome profile induced by an efficacious vaccine formulated with salivary antigens from cattle ticks.PMC69203532012/04087-02012/15464-0Gonzalez-Porta MGustavo Gardinassi Lde Miranda-Santos IKFCarvalho BVerissimo CJRung JMaruyama SRFerreira BRBrazma AKatiki LMBanin TMfalseBlood transcriptome profile induced by an efficacious vaccine formulated with salivary antigens from cattle ticks.Ticks cause massive damage to livestock and vaccines are one sustainable alternative for the acaricide poisons currently heavily used to control infestations. An experimental vaccine adjuvanted with alum and composed by four recombinant salivary antigens mined with reverse vaccinology from a transcriptome of salivary glands from <i>Rhipicephalus microplus</i> ticks was previously shown to present an overall efficacy of 73.2% and cause a significant decrease of tick loads in artificially tick-infested, immunized heifers; this decrease was accompanied by increased levels of antigen-specific IgG1 and IgG2 antibodies, which were boosted during a challenge infestation. In order to gain insights into the systemic effects induced by the vaccine and by the tick challenge we now report the gene exp2019-01-01T00:00:00Z20192025-05-29T16:07:21.104Z2020-05-22T00:49:03ZS-EPMC69203533187177310.1038/s41541-019-0145-1