{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang X"],"funding":["American Cancer Society","National Cancer Institute","NCI NIH HHS","University of Texas MD Anderson Cancer Center","Cancer Prevention and Research Institute of Texas"],"pagination":["1233"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6921460"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>Mouse and human studies support the promise of dry beans to improve metabolic health and to lower cancer risk. In overweight/obese patients with a history of colorectal polyps or cancer, the Beans to Enrich the Gut microbiome vs. Obesity's Negative Effects (BE GONE) trial will test whether and how an increase in the consumption of pre-cooked, canned dry beans within the context of usual diet and lifestyle can enhance the gut landscape to improve metabolic health and reduce cancer risk.<h4>Methods/design</h4>This randomized crossover trial is designed to characterize changes in (1) host markers spanning lipid metabolism, inflammation, and obesity-related cancer risk; (2) compositional and functional profiles of the fecal microbiome; and (3) host and microbial metabolites."],"journal":["BMC cancer"],"pubmed_title":["The BE GONE trial study protocol: a randomized crossover dietary intervention of dry beans targeting the gut microbiome of overweight and obese patients with a history of colorectal polyps or cancer."],"pmcid":["PMC6921460"],"funding_grant_id":["5P30 CA016672-37","P30 CA016672","Institutional Research Grant","RSG-17-049-01-NEC","RP160097"],"pubmed_authors":["Hanash SM","Basen-Engquist KM","Petrosino JF","Kopetz S","Browman G","Siu W","Zhang X","Okhuysen PC","Daniel CR","Scheet P","Hoffman KL"],"additional_accession":[]},"is_claimable":false,"name":"The BE GONE trial study protocol: a randomized crossover dietary intervention of dry beans targeting the gut microbiome of overweight and obese patients with a history of colorectal polyps or cancer.","description":"<h4>Background</h4>Mouse and human studies support the promise of dry beans to improve metabolic health and to lower cancer risk. In overweight/obese patients with a history of colorectal polyps or cancer, the Beans to Enrich the Gut microbiome vs. Obesity's Negative Effects (BE GONE) trial will test whether and how an increase in the consumption of pre-cooked, canned dry beans within the context of usual diet and lifestyle can enhance the gut landscape to improve metabolic health and reduce cancer risk.<h4>Methods/design</h4>This randomized crossover trial is designed to characterize changes in (1) host markers spanning lipid metabolism, inflammation, and obesity-related cancer risk; (2) compositional and functional profiles of the fecal microbiome; and (3) host and microbial metabolites.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-04-04T08:48:29.61Z","creation":"2020-05-22T01:08:15Z"},"accession":"S-EPMC6921460","cross_references":{"pubmed":["31852462"],"doi":["10.1186/s12885-019-6400-z"]}}