{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Meisel CL"],"funding":["Boston University","NIAID NIH HHS","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["4927-4939"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6924636"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1(9)"],"pubmed_abstract":["The impact of the protein-rich <i>in vivo</i> environment on targeted binding of functionalized nanoparticles has been an active field of research over the past several years. Current research aims at better understanding the nature of the protein corona and how it may be possible for targeted binding to occur even in the presence of serum. Much of the current research focuses on nanoparticles targeted to particular cell receptors or features with the aim of cellular uptake. However, similar research has not been performed on nanoparticles that are targeted to non-protein disease features, such as hydroxyapatite (HA). HA is a crystalline calcium-phosphate mineral that is present in large quantities in bone, and in smaller quantities in diseased cardiovascular tissue in cases of atheroscler"],"journal":["ACS applied nano materials"],"pubmed_title":["Targeted Nanoparticle Binding to Hydroxyapatite in a High Serum Environment for Early Detection of Heart Disease."],"pmcid":["PMC6924636"],"funding_grant_id":["T32 HL007969","T32 GM008541","T32 AI089673"],"pubmed_authors":["Mitsouras D","Meisel CL","Wong JY","Bainbridge P"],"additional_accession":[]},"is_claimable":false,"name":"Targeted Nanoparticle Binding to Hydroxyapatite in a High Serum Environment for Early Detection of Heart Disease.","description":"The impact of the protein-rich <i>in vivo</i> environment on targeted binding of functionalized nanoparticles has been an active field of research over the past several years. Current research aims at better understanding the nature of the protein corona and how it may be possible for targeted binding to occur even in the presence of serum. Much of the current research focuses on nanoparticles targeted to particular cell receptors or features with the aim of cellular uptake. However, similar research has not been performed on nanoparticles that are targeted to non-protein disease features, such as hydroxyapatite (HA). HA is a crystalline calcium-phosphate mineral that is present in large quantities in bone, and in smaller quantities in diseased cardiovascular tissue in cases of atheroscler","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2025-04-18T17:52:44.794Z","creation":"2020-10-29T13:18:31Z"},"accession":"S-EPMC6924636","cross_references":{"pubmed":["31867573"],"doi":["10.1021/acsanm.8b01099"]}}