{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Mi Z"],"pubmed_abstract":["Maternal immune activation (MIA) and juvenile social isolation (SI) are two most prevalent and widely accepted environmental insults that could increase the propensity of psychiatric illnesses. Using a two-hit mouse model, we examined the impact of the combination of these two factors on animal behaviors, neuronal excitability and expressions of voltage-gated sodium (Nav) and small conductance calcium-activated potassium (SK) channels in the prefrontal cortex (PFC). We found that MIA-SI induced a number of schizophrenia-related behavioral deficits. Patch clamp recordings revealed alterations in electrophysiological properties of PFC layer-5 pyramidal cells, including hyperpolarized resting membrane potential (RMP), increased input resistance and enhanced medium after-hyperpolarization (mAH"],"journal":["Frontiers in cellular neuroscience"],"pagination":["554"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6927988"],"repository":["biostudies-literature"],"pubmed_title":["Alterations of Electrophysiological Properties and Ion Channel Expression in Prefrontal Cortex of a Mouse Model of Schizophrenia."],"pmcid":["PMC6927988"],"pubmed_authors":["Mi Z","Yang J","Zhang X","Xiao Y","Shu Y","He Q"],"additional_accession":[]},"is_claimable":false,"name":"Alterations of Electrophysiological Properties and Ion Channel Expression in Prefrontal Cortex of a Mouse Model of Schizophrenia.","description":"Maternal immune activation (MIA) and juvenile social isolation (SI) are two most prevalent and widely accepted environmental insults that could increase the propensity of psychiatric illnesses. Using a two-hit mouse model, we examined the impact of the combination of these two factors on animal behaviors, neuronal excitability and expressions of voltage-gated sodium (Nav) and small conductance calcium-activated potassium (SK) channels in the prefrontal cortex (PFC). We found that MIA-SI induced a number of schizophrenia-related behavioral deficits. Patch clamp recordings revealed alterations in electrophysiological properties of PFC layer-5 pyramidal cells, including hyperpolarized resting membrane potential (RMP), increased input resistance and enhanced medium after-hyperpolarization (mAH","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-18T17:56:11.636Z","creation":"2020-05-22T07:37:29Z"},"accession":"S-EPMC6927988","cross_references":{"pubmed":["31920555"],"doi":["10.3389/fncel.2019.00554"]}}