biostudies-literatureUnknown6(12)Boyd A<h4>Background</h4>HIV-infected individuals undergoing effective antiretroviral therapy (ART) present an increased risk of atherosclerotic cardiovascular disease. We identified serum metabolites associated with carotid intima-media thickness (c-IMT) and its evolution.<h4>Methods</h4>One hundred forty-three hydrophilic serum metabolites were measured by ultraperformance liquid chromatography coupled with high-resolution mass spectrometry in 49 HIV+ ART+, 48 HIV+ ART-naïve and 50 HIV-negative, age-matched, never-smoking male triads. Metabolites differentially altered between groups ("features") were defined as having a Benjamini-Hochberg-adjusted <i>P</i> value <.05 from a <i>t</i> test and >0.25 log₂ absolute mean fold change in metabolite levels. c-IMT was measured across 12 sitOpen forum infectious diseasesofz516https://www.ebi.ac.uk/biostudies/studies/S-EPMC6929253biostudies-literatureSerum Tryptophan-Derived Quinolinate and Indole-3-Acetate Are Associated With Carotid Intima-Media Thickness and its Evolution in HIV-Infected Treated Adults.PMC6929253Boccara FBastard JPSauce DCollaboration in HIV, Inflammation and Cardiovascular Disease studyAutran BBoyd AGirard PMMeynard JLCohen ACapeau JFellahi SSamri AHaddour NIchou FfalseSerum Tryptophan-Derived Quinolinate and Indole-3-Acetate Are Associated With Carotid Intima-Media Thickness and its Evolution in HIV-Infected Treated Adults.<h4>Background</h4>HIV-infected individuals undergoing effective antiretroviral therapy (ART) present an increased risk of atherosclerotic cardiovascular disease. We identified serum metabolites associated with carotid intima-media thickness (c-IMT) and its evolution.<h4>Methods</h4>One hundred forty-three hydrophilic serum metabolites were measured by ultraperformance liquid chromatography coupled with high-resolution mass spectrometry in 49 HIV+ ART+, 48 HIV+ ART-naïve and 50 HIV-negative, age-matched, never-smoking male triads. Metabolites differentially altered between groups ("features") were defined as having a Benjamini-Hochberg-adjusted <i>P</i> value <.05 from a <i>t</i> test and >0.25 log₂ absolute mean fold change in metabolite levels. c-IMT was measured across 12 sit2019-01-01T00:00:00Z2019 Dec2025-04-04T20:43:51.81Z2020-05-22T01:16:52ZS-EPMC69292533189072210.1093/ofid/ofz516