{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Weber RE"],"funding":["Horizon 2020 Framework Programme"],"pubmed_abstract":["One of the most demanding challenges in infection control is the worldwide dissemination of multidrug-resistant (MDR) bacteria in clinical settings. Especially the increasing prevalence of carbapenemase producing Gram-negative pathogens poses an urgent threat to public health, as these enzymes confer resistance to almost all β-lactam antibiotics including carbapenems. In this study, we report a prolonged nosocomial outbreak of various NDM-1-producing <i>Enterobacterales</i> species due to clonal spread and cross-species exchange of plasmids and possibly transposons. Between July 2015 and September 2017, a total of 51 carbapenemase-positive isolates were collected from 38 patients and three environmental sources in a single German hospital. Combining molecular typing methods and whole genom"],"journal":["Frontiers in microbiology"],"pagination":["2817"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6929489"],"repository":["biostudies-literature"],"pubmed_title":["IS<i>26</i>-Mediated Transfer of <i>bla</i> <sub>NDM-1</sub> as the Main Route of Resistance Transmission During a Polyclonal, Multispecies Outbreak in a German Hospital."],"pmcid":["PMC6929489"],"pubmed_authors":["Pietsch M","Gatermann S","Weber RE","Luft D","Pfennigwerth N","Pfeifer Y","Martin M","Kaase M","Fuchs S","Fruhauf A","Werner G"],"additional_accession":[]},"is_claimable":false,"name":"IS<i>26</i>-Mediated Transfer of <i>bla</i> <sub>NDM-1</sub> as the Main Route of Resistance Transmission During a Polyclonal, Multispecies Outbreak in a German Hospital.","description":"One of the most demanding challenges in infection control is the worldwide dissemination of multidrug-resistant (MDR) bacteria in clinical settings. Especially the increasing prevalence of carbapenemase producing Gram-negative pathogens poses an urgent threat to public health, as these enzymes confer resistance to almost all β-lactam antibiotics including carbapenems. In this study, we report a prolonged nosocomial outbreak of various NDM-1-producing <i>Enterobacterales</i> species due to clonal spread and cross-species exchange of plasmids and possibly transposons. Between July 2015 and September 2017, a total of 51 carbapenemase-positive isolates were collected from 38 patients and three environmental sources in a single German hospital. Combining molecular typing methods and whole genom","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-05-04T09:02:13.545Z","creation":"2020-05-22T07:37:49Z"},"accession":"S-EPMC6929489","cross_references":{"pubmed":["31921015"],"doi":["10.3389/fmicb.2019.02817"]}}