{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen YC"],"funding":["Ministry of Science and Technology, Taiwan","Brain research center, National Yang-Ming University from The Featured Areas Research program within the framework of the Higher Education Sprout Project by the Ministry of Education in Taiwan","Taipei Medical University"],"pagination":["19787"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6930267"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Aerobic exercise, in relation to physical activity, has been shown to have beneficial effects on anxiety. However, the underlyig neural mechanism remains elusive. Using a within-subject crossover design, this fMRI study examined how exercise (12-min treadmill running versus walking) mediated amygdala reactivity to explicit and implicit (backward masked) perception of emotional faces in young adults (N = 40). Results showed that acute exercise-induced differences of state anxiety (STAI-S) varied as a function of individual's habitual physical activity (IPAQ). Subjects with high IPAQ levels showed significant STAI-S reduction (P < 0.05). Path analyses indicated that IPAQ explained 14.67% of the variance in acute exercise-induced STAI-S differences. Running elicited stronger amygdala reactivity to implicit happiness than fear, whereas walking did the opposite. The exercise-induced amygdala reactivity to explicit fear was associated with the IPAQ scores and STAI-S differences. Moreover, after running, the amygdala exhibited a positive functional connectivity with the orbitofrontal cortex and insula to implicit happiness, but a negative connectivity with the parahippocampus and subgenual cingulate to implicit fear. The findings suggest that habitual physical activity could mediate acute exercise-induced anxiolytic effects in regards to amygdala reactivity, and help establish exercise training as a form of anxiolytic therapy towards clinical applications."],"journal":["Scientific reports"],"pubmed_title":["Habitual physical activity mediates the acute exercise-induced modulation of anxiety-related amygdala functional connectivity."],"pmcid":["PMC6930267"],"funding_grant_id":["TMU106-AE1-B32","106-2410-H-010-002-MY2"],"pubmed_authors":["Martinez RM","Etnier JL","Chen YC","Chen C","Cheng Y"],"additional_accession":[]},"is_claimable":false,"name":"Habitual physical activity mediates the acute exercise-induced modulation of anxiety-related amygdala functional connectivity.","description":"Aerobic exercise, in relation to physical activity, has been shown to have beneficial effects on anxiety. However, the underlyig neural mechanism remains elusive. Using a within-subject crossover design, this fMRI study examined how exercise (12-min treadmill running versus walking) mediated amygdala reactivity to explicit and implicit (backward masked) perception of emotional faces in young adults (N = 40). Results showed that acute exercise-induced differences of state anxiety (STAI-S) varied as a function of individual's habitual physical activity (IPAQ). Subjects with high IPAQ levels showed significant STAI-S reduction (P < 0.05). Path analyses indicated that IPAQ explained 14.67% of the variance in acute exercise-induced STAI-S differences. Running elicited stronger amygdala reactivity to implicit happiness than fear, whereas walking did the opposite. The exercise-induced amygdala reactivity to explicit fear was associated with the IPAQ scores and STAI-S differences. Moreover, after running, the amygdala exhibited a positive functional connectivity with the orbitofrontal cortex and insula to implicit happiness, but a negative connectivity with the parahippocampus and subgenual cingulate to implicit fear. The findings suggest that habitual physical activity could mediate acute exercise-induced anxiolytic effects in regards to amygdala reactivity, and help establish exercise training as a form of anxiolytic therapy towards clinical applications.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2024-02-15T00:31:13.32Z","creation":"2020-05-22T00:49:57Z"},"accession":"S-EPMC6930267","cross_references":{"pubmed":["31875047"],"doi":["10.1038/s41598-019-56226-z"]}}