{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chang FP"],"funding":["Chinese Medicine Research Center, China Medical University","Taiwan Ministry of Health and Welfare Clinical Trial Center"],"pagination":["E4271"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6930649"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(23)"],"pubmed_abstract":["One new iridoid, namely neonanin C (<b>1</b>) one monocyclic iridoid ring-opened derivative namely neonanin D <b>(2)</b>, two new bis-iridoid derivatives namely reticunin A (<b>3</b>) and reticunin B (<b>4</b>) with sixteen known compounds (<b>5</b>-<b>20</b>) were isolated from the stems of <i>Neonauclea reticulata</i> (Havil.) Merr. These new structures were determined by the detailed analysis of spectroscopic data and comparison with the data of known analogues. Compounds <b>1</b>-<b>20</b> were evaluated for inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages cell line. The results showed that all compounds exhibited no obvious cytotoxicity compared to the control group and five compounds including isoboonein (<b>7</b>), syringaresinol (<b>10</b>), (+)-medioresinol (<b>12</b>), protocatechuic acid (<b>14</b>) and <i>trans</i>-caffeic acid (<b>15</b>) exhibited inhibitory activities with IC<sub>50</sub> values at 86.27 ± 3.45; 9.18 ± 1.90; 76.18 ± 2.42; 72.91 ± 4.97 and 95.16 ± 1.20 µg/mL, respectively."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Four New Iridoid Metabolites Have Been Isolated from the Stems of <i>Neonauclea reticulata</i> (Havil.) Merr. with Anti-Inflammatory Activities on LPS-Induced RAW264.7 Cells."],"pmcid":["PMC6930649"],"funding_grant_id":["CMRC-CHM-4","MOHW108-TDU-B-212-133004"],"pubmed_authors":["Huang SS","Kuo TF","Kuo YH","Lee TH","Huang GJ","Chang CI","Chang FP"],"additional_accession":[]},"is_claimable":false,"name":"Four New Iridoid Metabolites Have Been Isolated from the Stems of <i>Neonauclea reticulata</i> (Havil.) Merr. with Anti-Inflammatory Activities on LPS-Induced RAW264.7 Cells.","description":"One new iridoid, namely neonanin C (<b>1</b>) one monocyclic iridoid ring-opened derivative namely neonanin D <b>(2)</b>, two new bis-iridoid derivatives namely reticunin A (<b>3</b>) and reticunin B (<b>4</b>) with sixteen known compounds (<b>5</b>-<b>20</b>) were isolated from the stems of <i>Neonauclea reticulata</i> (Havil.) Merr. These new structures were determined by the detailed analysis of spectroscopic data and comparison with the data of known analogues. Compounds <b>1</b>-<b>20</b> were evaluated for inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages cell line. The results showed that all compounds exhibited no obvious cytotoxicity compared to the control group and five compounds including isoboonein (<b>7</b>), syringaresinol (<b>10</b>), (+)-medioresinol (<b>12</b>), protocatechuic acid (<b>14</b>) and <i>trans</i>-caffeic acid (<b>15</b>) exhibited inhibitory activities with IC<sub>50</sub> values at 86.27 ± 3.45; 9.18 ± 1.90; 76.18 ± 2.42; 72.91 ± 4.97 and 95.16 ± 1.20 µg/mL, respectively.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2025-04-05T16:21:19.542Z","creation":"2020-05-22T00:46:23Z"},"accession":"S-EPMC6930649","cross_references":{"pubmed":["31771186"],"doi":["10.3390/molecules24234271"]}}