biostudies-literatureHira VVVjavna agencija za raziskovalno dejavnost rsFondation pour la Recherche Nuovo-Soldati 2019kwf kankerbestrijdingEuropean Program of Cross-Border Cooperation for Slovenia-Italy Interreg TRANS-GLIOMA33-57https://www.ebi.ac.uk/biostudies/studies/S-EPMC6931169biostudies-literatureUnknown68(1)Glioblastoma is the most aggressive primary brain tumor. Slowly dividing and therapy-resistant glioblastoma stem cells (GSCs) reside in protective peri-arteriolar niches and are held responsible for glioblastoma recurrence. Recently, we showed similarities between GSC niches and hematopoietic stem cell (HSC) niches in bone marrow. Acute myeloid leukemia (AML) cells hijack HSC niches and are transformed into therapy-resistant leukemic stem cells (LSCs). Current clinical trials are focussed on removal of LSCs out of HSC niches to differentiate and to become sensitized to chemotherapy. In the present study, we elaborated further on these similarities by immunohistochemical analyses of 17 biomarkers in paraffin sections of human glioblastoma and human bone marrow. We found all 17 biomarkers toThe journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietySimilarities Between Stem Cell Niches in Glioblastoma and Bone Marrow: Rays of Hope for Novel Treatment Strategies.PMC6931169Programme P10245; TLKWF; UVA 2014-6839 and UVA 2016.1-10460; VVVH, MK, RJM, CJFVNProgramme 2017; TLBreznik BHira VVVVan Noorden CJFMlakar JLoncq de Jong AOostra RJLah TKhurshed MVittori MMolenaar RJfalseSimilarities Between Stem Cell Niches in Glioblastoma and Bone Marrow: Rays of Hope for Novel Treatment Strategies.Glioblastoma is the most aggressive primary brain tumor. Slowly dividing and therapy-resistant glioblastoma stem cells (GSCs) reside in protective peri-arteriolar niches and are held responsible for glioblastoma recurrence. Recently, we showed similarities between GSC niches and hematopoietic stem cell (HSC) niches in bone marrow. Acute myeloid leukemia (AML) cells hijack HSC niches and are transformed into therapy-resistant leukemic stem cells (LSCs). Current clinical trials are focussed on removal of LSCs out of HSC niches to differentiate and to become sensitized to chemotherapy. In the present study, we elaborated further on these similarities by immunohistochemical analyses of 17 biomarkers in paraffin sections of human glioblastoma and human bone marrow. We found all 17 biomarkers to2020-01-01T00:00:00Z2020 Jan2026-04-29T21:30:30.762Z2021-02-20T17:33:58ZS-EPMC69311693156607410.1369/0022155419878416