{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(23)"],"submitter":["Zhou PY"],"pubmed_abstract":["BACKGROUND:Mixed evidence challenges preoperative alpha-fetoprotein (AFP) as an independent prognostic factor for patients with hepatocellular carcinoma (HCC) after hepatectomy. RESULTS:Daily post-operative decrease of AFP by 9% as compared to the preoperative level (A09) were selected as the Cut-off. The Kaplan-Meier curve showed that A09 was significantly different for OS (P=0.043) and RFS (P=0.03). A decrease in risk by 54% was observed for OS and 32% for RFS in the at-risk population (A09>9%). A better concordance was observed after adding A09 into TNM and BCLC staging systems. Moreover, a consistent concordance was observed in the internal (FDZS5:0.63; FDZS3:0.608) and external (FDZS5:0.85; FDZS3:0.762) validation cohorts, suggesting its prognostic value in HCC population with elevate"],"journal":["Aging"],"pagination":["11111-11123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6932889"],"repository":["biostudies-literature"],"pubmed_title":["Daily decrease of post-operative alpha-fetoprotein by 9% discriminates prognosis of HCC: A multicenter retrospective study."],"pmcid":["PMC6932889"],"pubmed_authors":["Qu WF","Yang CP","Yi Y","Zhou YF","Guan RY","Tian MX","Wang H","Dai Z","Sun BY","Zhou PY","Fan J","Zhou C","Peng YF","Shi YH","Jiang XF","Zhou J","Tang Z","Huang JL","Song SS","Liu WR","Qiu SJ","Fang Y","Gong GZ","Tao CY","Ding ZB","Gan W","Liu G"],"additional_accession":[]},"is_claimable":false,"name":"Daily decrease of post-operative alpha-fetoprotein by 9% discriminates prognosis of HCC: A multicenter retrospective study.","description":"BACKGROUND:Mixed evidence challenges preoperative alpha-fetoprotein (AFP) as an independent prognostic factor for patients with hepatocellular carcinoma (HCC) after hepatectomy. RESULTS:Daily post-operative decrease of AFP by 9% as compared to the preoperative level (A09) were selected as the Cut-off. The Kaplan-Meier curve showed that A09 was significantly different for OS (P=0.043) and RFS (P=0.03). A decrease in risk by 54% was observed for OS and 32% for RFS in the at-risk population (A09>9%). A better concordance was observed after adding A09 into TNM and BCLC staging systems. Moreover, a consistent concordance was observed in the internal (FDZS5:0.63; FDZS3:0.608) and external (FDZS5:0.85; FDZS3:0.762) validation cohorts, suggesting its prognostic value in HCC population with elevate","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-05-29T21:28:26.836Z","creation":"2025-05-29T21:28:26.836Z"},"accession":"S-EPMC6932889","cross_references":{"pubmed":["31829979"],"doi":["10.18632/aging.102513"]}}