biostudies-literatureUnknown7Nixon BOxidative stress is a leading causative agent in the defective sperm function associated with male infertility. Such stress commonly manifests via the accumulation of pathological levels of the electrophilic aldehyde, 4-hydroxynonenal (4HNE), generated as a result of lipid peroxidation. This highly reactive lipid aldehyde elicits a spectrum of cytotoxic lesions owing to its propensity to form stable adducts with biomolecules. Notably however, not all elements of the sperm proteome appear to display an equivalent vulnerability to 4HNE modification, with only a small number of putative targets having been identified to date. Here, we validate one such target of 4HNE adduction, A-Kinase Anchor Protein 4 (AKAP4); a major component of the sperm fibrous sheath responsible for regulating the signFrontiers in cell and developmental biology319https://www.ebi.ac.uk/biostudies/studies/S-EPMC6933317biostudies-literatureA Kinase Anchor Protein 4 Is Vulnerable to Oxidative Adduction in Male Germ Cells.PMC6933317Eamens ALDe Iuliis GNDun MDTrigg NALord TAnderson ALBromfield EGDelehedde MNixon BSergeant NBernstein IRCafe SLfalseA Kinase Anchor Protein 4 Is Vulnerable to Oxidative Adduction in Male Germ Cells.Oxidative stress is a leading causative agent in the defective sperm function associated with male infertility. Such stress commonly manifests via the accumulation of pathological levels of the electrophilic aldehyde, 4-hydroxynonenal (4HNE), generated as a result of lipid peroxidation. This highly reactive lipid aldehyde elicits a spectrum of cytotoxic lesions owing to its propensity to form stable adducts with biomolecules. Notably however, not all elements of the sperm proteome appear to display an equivalent vulnerability to 4HNE modification, with only a small number of putative targets having been identified to date. Here, we validate one such target of 4HNE adduction, A-Kinase Anchor Protein 4 (AKAP4); a major component of the sperm fibrous sheath responsible for regulating the sign2019-01-01T00:00:00Z20192026-04-08T01:30:54.765Z2020-05-22T07:38:37ZS-EPMC69333173192183810.3389/fcell.2019.00319