{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vadillo E"],"funding":["Consejo Nacional de Ciencia y Tecnología","Royal Society"],"pagination":["26752-26758"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6936681"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["116(52)"],"pubmed_abstract":["Neutrophil extravasation is a migratory event in response to inflammation that depends on cytoskeletal dynamics regulated by myosins. Myosin-1e (Myo1e) is a long-tailed class-I myosin that has not yet been studied in the context of neutrophil-endothelial interactions and neutrophil extravasation. Intravital microscopy of TNFα-inflamed cremaster muscles in Myo1e-deficient mice revealed that Myo1e is required for efficient neutrophil extravasation. Specifically, Myo1e deficiency caused increased rolling velocity, decreased firm adhesion, aberrant crawling, and strongly reduced transmigration. Interestingly, we observed a striking discontinuous rolling behavior termed \"intermittent rolling,\" during which Myo1e-deficient neutrophils showed alternating rolling and jumping movements. Surprisingl"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Intermittent rolling is a defect of the extravasation cascade caused by Myosin1e-deficiency in neutrophils."],"pmcid":["PMC6936681"],"funding_grant_id":["284292","NAF/R1/180017"],"pubmed_authors":["Chanez-Paredes S","Guerrero-Fonseca IM","Vargas-Robles H","Giron-Perez DA","Garcia-Ponce A","Schnoor M","Nava P","Vadillo E","Santos-Argumedo L","Castellanos-Martinez R"],"additional_accession":[]},"is_claimable":false,"name":"Intermittent rolling is a defect of the extravasation cascade caused by Myosin1e-deficiency in neutrophils.","description":"Neutrophil extravasation is a migratory event in response to inflammation that depends on cytoskeletal dynamics regulated by myosins. Myosin-1e (Myo1e) is a long-tailed class-I myosin that has not yet been studied in the context of neutrophil-endothelial interactions and neutrophil extravasation. Intravital microscopy of TNFα-inflamed cremaster muscles in Myo1e-deficient mice revealed that Myo1e is required for efficient neutrophil extravasation. Specifically, Myo1e deficiency caused increased rolling velocity, decreased firm adhesion, aberrant crawling, and strongly reduced transmigration. Interestingly, we observed a striking discontinuous rolling behavior termed \"intermittent rolling,\" during which Myo1e-deficient neutrophils showed alternating rolling and jumping movements. Surprisingl","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2026-05-06T22:28:52.142Z","creation":"2026-04-07T22:28:14.834Z"},"accession":"S-EPMC6936681","cross_references":{"pubmed":["31811025"],"doi":["10.1073/pnas.1902502116"]}}